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Diabetes in Childhood and Adolescence
Diabetes mellitus is one of the most frequent chronic diseases affecting children and adolescents. The number of young children being diagnosed with type 1 diabetes is increasing worldwide and an epidemic of type 2 diabetes already at a young age is being
Medical Data Analysis
The 2nd International Symposium on Medical Data Analysis (ISMDA 2001) was the continuation of the successful ISMDA 2000, a conference held in Fra- furt, Germany, in September 2000. The ISMDA conferences were conceived to integrate interdisciplinary research from scienti?c ?elds such as statistics, s- nal processing, medical informatics, data mining, and biometrics for biomedical data analysis. A number of academic and professional people from those ?elds, including computer scientists, statisticians, physicians, engineers, and others, - alized that new approaches were needed to apply successfully all the traditional techniques, methods, and tools of data analysis to medicine. ISMDA 2001, as ...
List of Members
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Frequency and Characteristics of Diabetes in Lipodystrophies and Insulin Receptoropathies Compared with Type 1 and Type 2: Results from the Multicenter DPV Registry
Abstract: Objective To investigate the frequency, treatment, and outcome of patients with diabetes due to severe insulin resistance syndromes (SIRS). Research Design and Methods Based on data from the multicenter prospective Diabetes Registry DPV, we analyzed diagnosis, treatment, and outcome of 636,777 patients with diabetes from 1995 to 2022. Results Diabetes due to SIRS was documented in 67 cases (62.7% females), 25 (37%) had lipodystrophies (LD) and 42 (63%) had congenital defects of insulin signaling. The relative frequency compared to type 1 diabetes (T1D) was about 1:2300. Median age at diabetes diagnosis in patients with SIRS was 14.8 years (interquartile range (IQR) 12.8-33.8). A to...
Changes in Cardiovascular Risk Factors Among Children and Young Adults with Type 1 Diabetes During the COVID-19 Pandemic Compared to Previous Years - Results from the German DPV Registry
Abstract: Background The diverse stages of the COVID-19 pandemic led to several social circumstances that influenced daily life and health behavior. Purpose To evaluate changes in cardiovascular risk factors and physical activity among children and young adults with type 1 diabetes (T1D) during the COVID-19 pandemic in Germany compared to previous years. Methods A total of 32 785 individuals aged 6-21 years at baseline with T1D from the German diabetes patient follow-up (DPV) registry contributed data on 101 484 person-years between 2016 and 2021. The first treatment year of each individual within this period was considered as baseline. Based on trends from 2016 to 2019, we estimated differe...
An Analysis of DPV and DIVE Registry Patients with Chronic Kidney Disease According to the Finerenone Phase III Clinical Trial Selection Criteria
Abstract: Background The FIDELIO-DKD and FIGARO-DKD randomized clinical trials (RCTs) showed finerenone, a novel non-steroidal mineralocorticoid receptor antagonist (MRA), reduced the risk of renal and cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Using RCT inclusion and exclusion criteria, we analyzed the RCT coverage for patients with T2DM and CKD in routine clinical practice in Germany. Methods German patients from the DPV/DIVE registries who were ≥ 18 years, had T2DM and CKD (an estimated glomerular filtration rate [eGFR] 60 mL/min/1.73 m2 OR eGFR ≥ 60 mL/min/1.73m2 and albuminuria [≥ 30 mg/g]) were included. RCT inclusion ...
Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in Germany from 2002 to 2020: A Study Based on Electronic Health Record Data from the DPV Registry
Abstract: Background To provide estimates of the nationwide prevalence of type 1 diabetes (T1D) and type 2 diabetes (T2D) in individuals younger than 20 years of age in Germany from 2002 to 2020 and to identify trends. Methods Data were obtained from the electronic health record "Diabetes Prospective Follow-up Registry (DPV)" specific to diabetes care. Prevalence was estimated based on prevalent cases at the end of each year for the years 2002, 2008, 2014, and 2020 per 100 000 persons assuming a Poisson distribution and directly age- and/or sex-standardized to the population in 2020. Individuals younger than 20 years of age with a clinical diagnosis of T1D or 10-19-year-olds with T2D were el...
Onomatologie
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