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In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
Abstract: As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-flow) in aneurysmal arteries, platelets are subjected to external forces. Biomechanical platelet activation is incompletely understood and is a potential mechanism behind antiplatelet medication resistance. Although it has been demonstrated that antiplatelet drugs suppress the growth of abdominal aortic aneurysms (AAA) in patients, we found that a certain degree of platelet reactivity persisted in spite of aspirin therapy, urging us to consider additional antiplatelet therapeutic targets. Transcriptomic profiling of platelets from patients with AAA revealed upregulation of a signal trans...
This book provides a wide-ranging comparative analysis of contemporary economic, social, political and environmental change in small islands, island states and territories, through every ocean. It focuses on those island realms conventionally perceived as developing, rather than developed, in the Caribbean, Pacific and Indian Oceans. John Connell examines the decline of agriculture and the rise of tourism, the problems of urbanization, and the particular role of migration and remittances, within a culture of migration. He seeks to balance economic challenges with environmental threats, notably that of climate change, and social changes with the survival of culture, pointing to awkward and hybrid development futures. This unique study comprehensively balances environmental, social and economic changes to provide a more wide-ranging assessment of sustainability that will be invaluable for academics and postgraduate students on environment and international development courses.
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Forest wildlife conservation is critically required in many parts of the world today. This book presents a merger between the elements of wildlife conservation and habitat conservation, and explains how these disciplines can be used to promote the conservation of vertebrates in forests around the world.
Research in transfusion medicine is diverse and interdisciplinary, involving scientists and physicians in hematology, basic sciences, biology, biotechnology and so forth. It regularly proposes innovation from the donors to the patients along the whole transfusion chain in terms of blood screening, processing and transfusion praxis. The present Research Topic covers recent advances in transfusion medicine and blood, and provides an overview of the current knowledge. It includes original articles, reviews and perspectives for the future challenges.