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Photon-counting Computed Tomography (PC-CT) of the Spine: Impact on Diagnostic Confidence and Radiation Dose
Abstract: Objectives Computed tomography (CT) is employed to evaluate surgical outcome after spinal interventions. Here, we investigate the potential of multispectral photon-counting computed tomography (PC-CT) on image quality, diagnostic confidence, and radiation dose compared to an energy-integrating CT (EID-CT). Methods In this prospective study, 32 patients underwent PC-CT of the spine. Data was reconstructed in two ways: (1) standard bone kernel with 65-keV (PC-CTstd) and (2) 130-keV monoenergetic images (PC-CT130 keV). Prior EID-CT was available for 17 patients; for the remaining 15, an age-, sex-, and body mass index-matched EID-CT cohort was identified. Image quality (5-point Likert...
High Temporal Resolution Dual-source Photon-counting CT for Coronary Artery Disease: Initial Multicenter Clinical Experience
Abstract: The aim of this paper is to evaluate the diagnostic image quality of spectral dual-source photon-counting detector coronary computed tomography angiography (PCD-CCTA) for coronary artery disease in a multicenter study. The image quality (IQ), assessability, contrast-to-noise ratio (CNR), Agatston score, and radiation exposure were measured. Stenoses were quantified and compared with invasive coronary angiography, if available. A total of 92 subjects (65% male, age 58 ± 14 years) were analyzed. The prevalence of significant coronary artery disease (CAD) (stenosis ≥ 50%) was 17% of all patients, the range of the Agatston score was 0-2965 (interquartile range (IQR) 0-135). The IQ was very good (one, IQR one-two), the CNR was very high (20 ± 10), and 5% of the segments were rated non-diagnostic. The IQ and assessability were higher in proximal coronary segments (p
Werth und Overhoff
Der vorliegende Band 3 der Reihe Werth und Overhoff beinhaltet Ahnentafeln, Urkunden, Daten und Bilder meiner Vorfahren aus den Familien Werth und Overhoff. Es sind unter anderem die Daten aus den Tagebüchern in den Bänden 1 und 2 eingeflossen; aber auch die Sammlungen von Pfarrer Heinrich Keppler und von Gerold Overhoff sowie die Unterlagen meiner Mutter Dr. Erika Schröder. Zusammengefasst ergibt das eine umfassende Datensammlung über die Familien Werth und Overhoff.
Citizens in a Strange Land
In Citizens in a Strange Land, Hermann Wellenreuther examines the broadsides—printed single sheets—produced by the Pennsylvania German community. These broadsides covered topics ranging from local controversies and politics to devotional poems and hymns. Each one is a product of and reaction to a particular historical setting. To understand them fully, Wellenreuther systematically reconstructs Pennsylvania’s print culture, the material conditions of life, the problems German settlers faced, the demands their communities made on the individual settlers, the complications to be overcome, and the needs to be satisfied. He shows how these broadsides provided advice, projections, and comment on phases of life from cradle to grave.
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Formulating Poorly Water Soluble Drugs
The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining t...
