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Introduction to Fluorescence In Situ Hybridization
Introduction to Fluorescence in Situ Hybridization Principles and Clinical Applications Edited by Michael Andreeff, M.D., PH.D., and Daniel Pinkel, PH.D. Fluorescence In Situ Hybridization (FISH) has become an essential tool in the diagnosis and management of a variety of solid tumors and hematologic malignancies in the clinical setting, as well as an aid in the identification of particular genetic disorders. Introduction to Fluorescence In Situ Hybridization provides a solid groundwork in the basic principles and techniques of FISH and covers in detail the applications of this technology to cancer in humans, including tumorigenesis, prostate and breast tumors, myeloid leukemias, and lymphop...
Research Instrumentation for the 21st Century
The Annual Beltsville Symposium serves as a forum for presenting recent developments in basic research that contribute solutions to agricultural problems. The eleventh in this series focuses on instrumentation tech niques which provide powerful new research tools. These tools will provide information that can lead to a better understanding of biological and physical processes critical to the solution of today's agricultural problems. The tools discussed include isotope technology, separation techniques, microscopy, electro-magnetic spectroscopy, resonance and mass spectrometry and microcomputers. This Symposium brought together scientists who are at the forefront of the development of many o...
Human Genome
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Bacterial Artificial Chromosomes
Several developmental and historical threads are woven and displayed in these two volumes of Bacterial Artificial Chromosomes, the first on Library Construction, Physical Mapping, and Sequencing, and the second on Fu- tional Studies. The use of large-insert clone libraries is the unifying feature, with many diverse contributions. The editors have had quite distinct roles. Shaying Zhao has managed several BAC end-sequencing projects. Marvin Stodolsky during 1970–1980 contributed to the elucidation of the natural b- teriophage/prophage P1 vector system. Later, he became a member of the Genome Task Group of the Department of Energy (DOE), through which s- port flowed for most clone library re...
Life Histories of Genetic Disease
A history of genetic testing warns that such tests may tell us more than we want to know. Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today’s expecting parents to choose to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In Life Histories of Genetic Disease, Andrew J. Hogan explores how various diseases were “made genetic” after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, t...
Biological Dosimetry
In October 1982, a small international symposium was held at the Gesellschaft fUr Strahlen- und Umweltforschung mbH (GSF) in Munich as a satellite meeting of the IX International Conference on Analytical Cytology. The symposium focussed on cytometric approaches to biological dosimetry, and was, to the best of our knowledge, the first meeting on this subject ever held. There was strong encouragement from the 75 attendees and from others to publish a proceedings of the symposium. Hence this book, containing 30 of the 36 presentations, has been assembled. Dosimetry, the accurate and systematic determination of doses, usually refers to grams of substance administered or rads of ionization or some such measure of exposure of a patient, a victim or an experimental system. The term also can be used to describe the quantity of an ultimate, active agent as delivered to the appropriate target material within a biological system. Thus, for mutagens, one can speak of DNA dosimetry, meaning the number of adducts produced in the DNA of target cells such as bone-mar row stem cells or spermatogonia.
Living Dead in the Pacific
Colonized since the 1600s, Taiwan is largely a nation of settlers, yet within its population of twenty-three million are 500,000 Aboriginal people. In their quest to learn about disease and evolution, genetic researchers have eagerly studied this group over the past thirty years but have often disregarded the rights of their subjects. Examining a troubling revival of racially configured genetic research and the questions of sovereignty it raises, Living Dead in the Pacific details a history of exploitation and resistance that represents a new area of conflict facing Aboriginal people both within Taiwan and around the world.
