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Genetic Insights in Paediatric Endocrinology and Metabolism
Endocrine problems in children can be very distressing, not only for the patients concerned, but also for those close to them. Thanks to advances in the understanding of the genetic basis of disease and improved techniques for studying conditions at the molecular level, the mechanisms behind these problems are now far more widely understood.
Genetics in Growth, and Pituitary Tumorigenesis
This issue is a dedicated supplement published in addition to the regular issues of 'Hormone Research' focussing on one specific topic. 'Hormone Research' is a well-respected, international peer-reviewed journal in Endocrinology. Supplement issues are included in the subscription.
Paediatric Clinical Pharmacology
The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.
Growth Disorders 2E
Linear growth is a biological process of fundamental importance to the physical and psychological make-up of a child and adolescent but which can be subject to a number of interruptions and disorders. The management and treatment of patients with growth disorders constitues a major, and important, part of practice in clinical paediatrics, while in public health terms growth assessment remains one of the most useful indices of health and economic well being in both developed and the developing world. This book approaches growth and its disorders from both a physiological and pathophysiological standpoint. The book outlines in detail the fundamental biological mechanisms of normal and abnormal...
The House With Three Doors
LONDON 1946 - Terror jolted Sarah Richards out of her nightmare. Her screams awoke Brant Wilder, her lover, whose naked body entwined with hers beneath the sheet. Sarah's heart thumped. She was trembling. Her fair skin was cold. Brant comforted her, 'Ssh...ssh my darling...it's all right, you've had a bad dream...ssh...it'll soon fade away into nothing.' He warmed her with his body heat. With gentleness, he blew his hot breath in her ear, then brushed his lips across her cheek to her mouth, where he shushed her with kisses so passionate her legs opened to him. The way her gorgeous body yielded to his touch never failed to turn him on. He moved himself into her, and once more they became lost...
Evidence-Based Paediatric and Adolescent Diabetes
Evidence-based Paediatric and Adolescent Diabetes brings together an international group of paediatric diabetes specialists to address the cause, course and complications of all types of diabetes. From a careful review of the latest research, they propose the best possible evidence-based recommendations for the care of children and the youth with diabetes. The text provides the reader with an understanding across three different levels: • Reviews how strong the evidence is for recommending one approach over another • Highlights areas where evidence is not based on the types of studies needed to provide ‘highgrade recommendations’, but where there is a general consensus as to the most sensible approach • Identifies the issues that remain inadequately addressed such that no definitive recommendations can be made As the incidence of type 1 diabetes mellitus continues to increase worldwide, and type 2 is being seen in more young people, this timely volume will help a wide range of health care professionals deliver the best possible care to their young patients.
Growth Hormone Therapy in Pediatrics
For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders ...
Puberty from Bench to Clinic
Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the v...
Insulin Resistance
Now in a revised and expanded second edition, this unique text presents topics related to insulin resistance in youth and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of insulin resistance in children and what is known about how insulin resistance in youth differs from adults, the measurement of insulin resistance in youth in the research and clinical settings, and current knowledge regarding the epidemiology of insulin resistance in the pediatric population. The second section of the book explores pathophysiology, including current knowledge of the molecular, metabolic, and physiologi...
