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The Migraine Brain
The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
Imaging in CNS Drug Discovery and Development
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Bodyology
What it’s like to be hit by lightning or to lose your sense of smell? Have you heard about the woman saved by bee stings — or the window cleaner who fell 400ft and lived? Written for Wellcome charity's Mosaic Science site, these 16 stories explore the mysteries of the human body. Learn about everything from diets to allergies to baldness. Contents What’s it like to be struck by lightning?Why do we colour hair?The man with the golden bloodWhy dieters can’t rely on calories3D printers can now make body partsHow to fall from a skyscraper and live to tell the taleThe quest to explain miscarriagesSeeking a ‘cure’ for male baldnessHow bee stings saved a woman’s lifeThe global trend f...
Pathophysiology of Headaches
This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system a...
Knowing Pain
Pain, while known to almost everyone, is not universal. The evidence of our own pain, and our own experience, does not provide us with automatic insight into the pains of others, past or present. No matter how self-evident and ubiquitous the sting of a paper cut or the desolation of heartbreak might seem, pain is situated and historically specific. In a work that is sometimes personal, always political, Rob Boddice reveals a history of pain that juggles many disciplinary approaches and disparate languages to tackle the thorniest challenges in pain research. He explores the shifting meaning-making processes that produce painful experiences, expanding the world of pain to take seriously the re...
Neurobiological Basis of Migraine
Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the...
The Thief of Time
When we fail to achieve our goals, procrastination is often the culprit. But how exactly is procrastination to be understood? It has been described as imprudent, irrational, inconsistent, and even immoral, but there has been no sustained philosophical debate concerning the topic. This edited volume starts in on the task of integrating the problem of procrastination into philosophical inquiry. The focus is on exploring procrastination in relation to agency, rationality, and ethics-topics that philosophy is well-suited to address. Theoretically and empirically informed analyses are developed and applied with the aim of shedding light on a vexing practical problem that generates a great deal of frustration, regret, and harm. Some of the key questions that are addressed include the following: How can we analyze procrastination in a way that does justice to both its voluntary and its self-defeating dimensions? What kind of practical failing is procrastination? Is it a form of weakness of will? Is it the product of fragmented agency? Is it a vice? Given the nature of procrastination, what are the most promising coping strategies?
