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The potential involvement of neurogenic inflammation in the pathogenesis of the migraine headache and the inhibition of this mechanism as a possible mode of action of antimigraine medications are discussed in great depth in this volume. The topics are approached from a pathophysiological as well as a clinical experimental perspective by a renowned group of clinicians and scientists who carefully consider the current, future, and potential therapeutic approaches to migraine treatment. The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. Subsequent...
Impact evaluations are studies that attempt to measure the causal impact of a project, program, or policy on one or more outcomes. This book provides a comprehensive exposition of how to conduct impact evaluations. Part I provides an overview of impact evaluations and comprises five chapters which are accessible to readers who have few or none of the technical (statistical and econometric) skills that are needed to conduct impact evaluations. Parts II and III make use of statistical and econometric methods and are at a level similar to a graduate-student course but written to make them accessible to the ambitious reader whose skills are not at that level. Part II presents, in Chapters 6-10, ...
Investing as a business angel offers fun and financial reward but the real world is much tougher than portrayed in the reality TV show Dragons' Den. Anything can go wrong with a young company, from an unreliable product to a lack of customers, unexpected competition to management failure and, most commonly, simply running out of money. But small companies are a vital part of the economy, and the tax breaks for investing are a great incentive. And supportive investors are vital. Now is a better time than ever to invest in small companies hoping to make it big. There’s a tsunami of investable businesses disrupting old industries with new technology and new methods. The rewards can be huge if you are patient, sensible and smart. And there’s the satisfaction of helping to bring a new and valuable thing into the world. Whether you’re a newbie or an old hand, Business Angel Investing is your comprehensive guide on how to invest, what to invest in, how to manage your investments and how to make money. Richard Hargreaves has invested in young companies for almost 50 years. Let him show you how being a business angel can be fascinating, fun and profitable.
Advances in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
Proceedings of the NATO Advanced Research Workshop on Regulatory Mechanisms of Neuron to Vessel Communication in the Brain held in Salo, Italy, September 3-8, 1988
This account of the D-Day invasion—from the German point of view—includes maps and photos. The Allied invasion of Northern France was the greatest combined operation in the history of warfare. Up until now, it has been recorded from the attackers’ point of view—whereas the defenders’ angle has been largely ignored. While the Germans knew an invasion was inevitable, no one knew where or when it would fall. Those manning Hitler’s mighty Atlantic Wall may have felt secure in their bunkers, but they had no conception of the fury and fire that was about to break. After the initial assaults of June established an Allied bridgehead, a state of stalemate prevailed. The Germans fought with great courage—hindered by lack of supplies and overwhelming Allied control of the air. This book describes the catastrophe that followed, in a unique look at the war from the losing side.
Chapterwise Social Science Objective & Subjective Book for CBSE Class 10 Term II Exam 2022: 1500+ New Pattern Questions (MCQs, Extract Based)
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