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Imaging in CNS Drug Discovery and Development
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Mission Culture on the Upper Amazon
Until recently, historians of the Christian missions in the New World have seen Missionaries either as saints and martyrs or as brutal disrupters and oppressors. Both the apologists and detractors of mission enterprise have concentrated solely on the missionaries, regarding the native populations either as childlike beneficiaries or as mutely suffering victims. With the growth of ethnohistory as a field of research, new research has sought to reconstruct the situations, the reactions, and the strategies of native groups, thereby seeing the native peoples of the Americas as active agents in their own history. In Mission Culture on the Upper Amazon, David Block describes the formation of a new...
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Flowering Plants. Eudicots
This volume covers the orders Boraginales, Garryales and Solanales (except Convolvulaceae) of the Lamiids (Asterids I) as well as three unplaced families of that clade, i.e. Vahliaceae, Icacinaceae and Metteniusaceae, and the orders Aquifoliales, Escalloniales, Bruniales, Dipsacales and Paracryphiales of the Campanulids (Asterids II). It is the first of two final volumes to (almost) complete the treatment of the Asterids, which started with Vol. VI (Cornales, Ericales, 2004) and continued with Vol. VII (Lamiales, 2004) and Vol. VIII (Asterales, 2007). The present volume provides descriptions for 35 families and altogether 340 genera, including three genera of somewhat uncertain family affiliation. It provides identification keys for families within orders and for all genera within families, and also discusses probable phylogenetic relationships. The wealth of information contained in this volume makes it an indispensable source for all those working in pure and applied plant sciences.
Flowering Plants. Eudicots
This volume covers the orders Apiales (Asterids I) and Gentianales (except Rubiaceae; Asterids II). It is the last of five volumes to (almost) complete the treatment of the Asterids in this series after publication of Vols. VI (Cornales, Ericales, 2004), VII (Lamiales, 2004), VIII (Asterales, 2007) and XIV (Aquifoliales, Boraginales, Bruniales, Dipsacales, Escalloniales, Garryales, Paracryphiales, Solanales, Icacinaceae, Metteniusaceae, Vahliaceae, 2016). The present volume provides descriptions for 11 families with altogether 1021 genera. Identification keys are provided for families within orders and for all genera within families, and likely phylogenetic relationships are discussed. The wealth of information contained in this volume makes it an indispensable source for all working in pure and applied plant sciences.
Metals in Medicine
Working from basic chemical principles, Metals in Medicine, 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasit...
Dermatokinetics of Therapeutic Agents
Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders.Presenting the first compre
