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Mass Spectrometry in Drug Discovery
Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.
Sampling and Sample Preparation in Field and Laboratory
This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation. Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situ...
Handbook of Isolation and Characterization of Impurities in Pharmaceuticals
The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quali...
The Imperative Habit
Looking back at the life I lived years ago, I see a man who seemingly had it all. I ran my own companies since I was 28 years old. I married a beautiful woman. Together we brought three children into the world and, for 16 years, I ran a business with annual sales of $30 to $35 million. I collected all the hallmarks of the desired life—a big house in the hills bordering Silicon Valley, vacation homes, fully-loaded cars, boats, private schools for the kids, and exotic vacations for all of us. Only one thing was missing: I wasn't happy. I was much the opposite. And one day, everything fell apart, and I knew I had to make a change. By shedding my old belief systems and developing new ones, by ...
Unbearable Lightness
"I didn't decide to become anorexic. It snuck up on me disguised as a healthy diet, a professional attitude. Although there was a certain glamour to anorexics, I didn't want to be one. I just wanted to excel in dieting. And weighing in at 80 pounds on 300 calories a day, I was the best little dieter there ever was." In scalding prose, Portia de Rossi reveals the pain and illness that haunted her for decades. She alternately starved herself and binged, putting her life in danger and lying to herself and everyone around her about the depth of her illness. From her lowest point, Portia began the painful climb back to health and happiness, ultimately falling head over heels in love with Ellen DeGeneres. In this remarkable and landmark book, she tells a story that inspires hope and nourishes the spirit.
Rossi's Principles of Transfusion Medicine
Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references
Valentino Rossi
Valentino Rossi's retirement brings down the curtain on an incredible career in the MotoGP motorcycle world championships. With his nine titles, including seven in the premier class, he is widely regarded as the greatest motorcycle racer ever, and his 26 seasons of Grand Prix racing make him unique across both motorcycling and Formula 1. Rossi has been captivating fans since he won his first Grand Prix at the age of 17 and even in his final season, at the age of 42, he has been riding faster than ever. In Valentino Rossi: All His Races, by top journalist Mat Oxley, each and every one of these races comes under the microscope, complete with perspectives about Rossi's achievements, the controv...
The Philosophical View of the Great Perfection in the Tibetan Bon Religion
Dzogchen, or the Great Perfection, is considered by both the Bonpos and the followers of the Nyigma school in Tibet to be the culmination of all spiritual teachings. The philosophical view of the Great Perfection introduces the individual to the knowledge of reality, which is one with the enlightened state of all beings. In this book the Dzogchen view is presented in two Bonpo texts belonging to the revered terma (treasure) and oral traditions, here for the first time translated and critically edited in their entirety.
