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Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.
The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quali...
Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation. Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situ...
Success was not all Anthony Rossi found in America.At the age of 21, Anthony T. Rossi saw the Statue of Liberty for the first time as his ship entered New York harbor. Though he knew virtually no English, he found a job that very day as a machinist's assistant. Within a few years he bought a grocery store, then a farm, a cafeteria and then a large restaurant. Finally, in 1947 he founded Tropicana Products, Inc., which under his leadership became the largest fresh-chilled orange juice company in the world.Success was not all Rossi found in America. He also found a vibrant faith in God that touched his business and personal dealings daily. Eventually he established the Aurora Foundation that has funded Christian educational institutions, Christian missions and other charities.How did an immigrant from Italy with no formal education revolutionize the way fresh orange juice was transported from Florida to the rest of the country? What prepared him to be not only the giant of his industry but also an evangelist, church planter and leader in Christian missions?Here is the inspiring story of a man who stands as a model of energy, creativity and hope.
THE SUNDAY TIMES BESTSELLER 'THE ROCK 'N' ROLL AUTOBIOGRAPHY OF THE YEAR' MAIL ON SUNDAY 'Essential for fans and great reading for anyone else' Classic Rock Break-ups, make-ups, groupies, band politics, court battles, the tragic death of Rick Parfitt . . . This is Francis Rossi as you have never seen him before. Status Quo have sold over 100 million records worldwide, including 65 hit singles and 32 hit albums. The legendary band's career has mirrored the evolution of rock music. From the struggles of the flower-power '60s, the highs of the denim-clad '70s, the coke- and tequila-induced blur of the '80s, to fighting for musical integrity in the '90s and '00s and a fresh lease of life from ne...
"I didn't decide to become anorexic. It snuck up on me disguised as a healthy diet, a professional attitude. Although there was a certain glamour to anorexics, I didn't want to be one. I just wanted to excel in dieting. And weighing in at 80 pounds on 300 calories a day, I was the best little dieter there ever was." In scalding prose, Portia de Rossi reveals the pain and illness that haunted her for decades. She alternately starved herself and binged, putting her life in danger and lying to herself and everyone around her about the depth of her illness. From her lowest point, Portia began the painful climb back to health and happiness, ultimately falling head over heels in love with Ellen DeGeneres. In this remarkable and landmark book, she tells a story that inspires hope and nourishes the spirit.