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Aging is a major risk factor for several neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. The immune response is often dysregulated in aging, leading to a predisposition towards a state of chronic inflammation. The precise processes which support this inflammatory state are still a subject of debate, however, cell- and tissue-specific transcriptional changes in several immune-related genes have been identified as potential drivers. In addition to genetic changes, losses in the bacterial diversity within the microbiome are also observed during aging. However, it is unclear whether this may be a cause or consequence of inflammation. Host-microbiome interactions ar...
Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagno...
Communal violence, ethnonationalist insurgencies, terrorism, and state violence have marred the Indian natio- state since its inception. These phenomena frequently intersect with prevailing forms of gendered violence complicated by caste, religion, regional identity, and class within communities. Deepti Misri shows how Partition began a history of politicized animosity associated with the differing ideas of ""India"" held by communities and in regions on one hand, and by the political-military Indian state on the other. She moves beyond that formative national event, however, in order to examine other forms of gendered violence in the postcolonial life of the nation, including custodial rape...
Multihop Mobile Wireless Networks discusses issues pertaining to each of these networks and proposes novel and innovative algorithms on Scheduling, Routing and Data aggregation that are viable solutions for multihop mobile networks. Moreover, the book provides the preliminaries and an excellent review on existing approaches in wireless communications. Multihop Mobile Wireless Networks is suitable for academic and industrial research, and can be used for advanced courses in Senior Undergraduate and Graduate programs.
This volume contains the proceedings of the third international conference on Pattern Recognition and Machine Intelligence (PReMI 2009) which was held at the Indian Institute of Technology, New Delhi, India, during December 16–20, 2009. This was the third conference in the series. The first two conferences were held in December at the Indian Statistical Institute, Kolkata in 2005 and 2007. PReMI has become a premier conference in India presenting state-of-art research findings in the areas of machine intelligence and pattern recognition. The conference is also successful in encouraging academic and industrial interaction, and in prom- ing collaborative research and developmental activities...
Seventy-five years after Independence, India has much to be proud of. We are both the world’s biggest democracy and fastest-growing large economy. Yet, we face profound challenges that hinder both individual well-being and aggregate growth, including education and skills, health and nutrition, public safety, justice, social protection, and jobs. This seminal book systematically analyses India’s governance challenges, especially in delivering essential public services, and highlights how these are limiting India’s development. Drawing on a wealth of research and practical insights, it provides actionable, evidence-based strategies, emphasizing state-level reforms as critical for Indiaâ€...
The International Committee on Large Dams (ICOLD) held its 27th International Congress in Marseille, France (12-19 November 2021). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.