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AIDS Clinical Trials
AIDS CLINICAL TRIALS Edited by Dianne M. Finkelstein and David A. Schoenfeld Conducting trials for new drugs or regimens for the treatment of HIV or AIDS presents unique challenges to statisticians and clinical investigators. Not only must they have a clear understanding of the relevant regulatory issues and methods of statistical analysis, but they must also deal with various medical and social pressures that further complicate the design and implementation of clinical trials. AIDS Clinical Trials addresses the critical scientific, clinical, and regulatory issues involved in AIDS drug development and evaluation. The book provides the reader with detailed guidelines on the essential statisti...
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The Beginner's Guide to Interpreting Ethnic DNA Origins for Family History
Genealogists are now using molecular genealogy--comparing and matching people by matrilineal DNA lineages--mtDNA or patrilineal Y-chromosome ancestry and/or racial percentages tests. People interested in ancestry now look at genetic markers to trace the migrations of the human species. Here's how to trace your genealogy by DNA from your grandparents back 10,000 or more years. Anyone can be interested in DNA for ancestry research, but of interest to Jews from Eastern Europe is to see how different populations from a mosaic of communities reached their current locations. From who are you descended? What markers will shed light on your deepest ancestry? You can study DNA for medical reasons or to discover the geographic travels and dwelling places of some of your ancestors. How do Europeans in general fit into the great migrations of prehistory that took all to where they are today based on their genetic DNA markers and sequences? Where is the geographic center of their origin and the roots of all people? Specifically, how can you interpret your DNA test for family history as a beginner in researching ancestry and your own family history?
Statistical Methods for Cancer Studies
This book focuses on public health and epidemiologic aspects of cancer, and explores the sources of information concerning the frequency of occurrence of human cancer. It describes statistical methods useful in studying problems arising in the field of cancer and its concurrent development.
Valuing Health Care
As expenditure on health care has increasingly become an area of public debate and concern, public and private health care decision-makers have called for more rigorous use of cost-benefit and cost-effectiveness analysis to guide spending. Concerns have arisen, however, about the overall quality of such analyses. This book discusses and evaluates best-practice methods of conducting cost-benefit and cost-effectiveness studies of pharmaceuticals and other medical technologies. It encompasses a wide variety of topics, ranging from measuring cost and effectiveness to discounting to the use of dynamic modelling of cost-effectiveness. The book also includes conceptual and practical aspects of cost-effectiveness analysis by researchers who have conducted applied research in these areas. Rarely does the book provide a singular solution to a measurement problem; rather, the reader is directed to choices among alternative approaches and an analysis of the advantages and disadvantages of each.
NIAID AIDS Agenda
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No Family History
No Family History presents compelling evidence of environmental links to breast cancer, ranging from everyday cosmetics to industrial waste. Sabrina McCormick weaves the story of one survivor with no family history into a powerful exploration of the big business of breast cancer. As drugs, pink products, and corporate sponsorships generate enormous revenue to find a cure, a growing number of experts argue that we should instead increase focus on prevention—reducing environmental exposures that have contributed to the sharp increase of breast cancer rates. But the dollars continue to pour into the search for a cure, and the companies that profit, including some pharmaceutical and cosmetics companies, may in fact contribute to the environmental causes of breast cancer. No Family History shows how profits drive our public focus on the cure rather than prevention, and suggests new ways to reduce breast cancer rates in the future.
