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The SEER Program
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New and Emerging Proteomic Techniques
Leading researchers and innovators describe in step-by-step detail the latest techniques that promise to significantly impact the practice of proteomics, as well as its success in developing novel clinical agents. The methods span the entire spectrum of top-down and bottom-up approaches, including microarrays, gels, chromatography, and affinity separations, and address every aspect of the human proteome, both quantitatively and qualitatively. The techniques of protein detection utilized are diverse and range from fluorescence and resonance light scattering to surface plasmon resonance and mass spectrometry. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Epidermal Growth Factor
A comprehensive collection of optimized methods for dissecting the mechanisms that control epidermal growth factors (EGF) and their regulators in both normal and pathological states. These readily reproducible techniques range from the study of purified EGF receptor to complex signaling and processing networks in intact cells, including a chapter on the clinical and pharmacological considerations of their use in cancer therapy. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Manual of Catalan Linguistics
This manual is intended to fill a gap in the area of Romance studies. There is no introduction available so far that broadly covers the field of Catalan linguistics, neither in Catalan nor in any other language. The work deals with the language spoken in Catalonia and Andorra, the Balearic Islands, the region of Valencia, Northern Catalonia and the town of l'Alguer in Sardinia. Besides introducing the ideologies of language and nation and the history of Catalan linguistics, the manual is divided into separate parts embracing the description – grammar, lexicon, variation and varieties – and the history of the language since the early medieval period to the present day. It also covers its current social and political situation in the new local and global contexts. The main emphasis is placed on modern Catalan. The manual is designed as a companion for students of Catalan, while also introducing specialists of other languages into this field, in particular scholars of Romance languages.
Studies in Numismatic Method
Coins are one of the most abundant sources for our study of the past, yet their value as historical evidence is relatively neglected because of a general lack of knowledge of numismatic techniques. This volume of essays, offered by a circle of friends, colleagues and pupils working in Britain, Europe and North America, is intended to pay tribute to Philip Grierson's unique contribution to the study of numismatic method. A medievalist by training, through his wide-ranging interests in coins and coinage Grierson has commanded the respect of historians and numismatists of all periods for the originality and good sense of his prolific scholarship. More than any other living scholar, he has been responsible for making available an understanding of numismatic expertise to specialist and non-specialist audiences.
The Making of Modern Colombia
Colombia's status as the fourth largest nation in Latin America and third most populous—as well as its largest exporter of such disparate commodities as emeralds, books, processed cocaine, and cut flowers—makes this, the first history of Colombia written in English, a much-needed book. It tells the remarkable story of a country that has consistently defied modern Latin American stereotypes—a country where military dictators are virtually unknown, where the political left is congenitally weak, and where urbanization and industrialization have spawned no lasting populist movement. There is more to Colombia than the drug trafficking and violence that have recently gripped the world's atte...
Medicine Before the Plague
An account of the medical world in eastern Spain in the decades before the Black Death.
