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Proteostasis and Disease
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Sixteenth Marcel Grossmann Meeting, The: On Recent Developments In Theoretical And Experimental General Relativity, Astrophysics, And Relativistic Field Theories - Proceedings Of The Mg16 Meeting On General Relativity (In 4 Volumes)
The proceedings of MG16 give a broad view of all aspects of gravitational physics and astrophysics, from mathematical issues to recent observations and experiments. The scientific program of the meeting included 46 plenary presentations, 3 public lectures, 5 round tables and 81 parallel sessions arranged during the intense six-day online meeting. All talks were recorded and are available on the ICRANet YouTube channel at the following link: www.icranet.org/video_mg16.These proceedings are a representative sample of the very many contributions made at the meeting. They contain 383 papers, among which 14 come from the plenary sessions.The material represented in these proceedings cover the fol...
Introduction to Experimental Particle Physics
This book brings together the most important topics in experimental particle physics over the past forty years to give a brief but balanced overview of the subject. The author begins by reviewing particle physics and discussing electromagnetic and nuclear interactions. He then goes on to discuss three nearly universal aspects of particle physics experiments: beams, targets, and fast electronics. The second part of the book treats in detail the properties of various types of particle detector, such as scintillation counters, Cerenkov counters, proportional chambers, drift chambers, sampling calorimeters, and specialized detectors. Wherever possible the author attempts to enumerate the advantages and disadvantages of performance. Finally, he discusses aspects of specific experiments, such as properties of triggers, types of measurement, spectrometers, and the integration of detectors into coherent systems. Throughout the book, each chapter begins with a discussion of the basic principles involved, followed by selective examples.
Law of Administrative Organization of the EU
With the transfer of ever more tasks and competences to the European level the EU’s administration has become increasingly complex, with ‘agencification’ as the most visible sign of this differentiation. This book offers a much-needed analytical overview of the field, with the aim of improving our understanding of administration at the European level, and indeed of improving the administration itself.
The Shoulder
The Shoulder: Theory & Practice presents a comprehensive fusion of the current research knowledge and clinical expertise that will be essential for any clinician from any discipline who is involved with the assessment, management and rehabilitation of musculoskeletal conditions of the shoulder. This book is a team project-led by two internationally renowned researchers and clinicians, Jeremy Lewis and César Fernández-de-las-Peñas. Other members of the team include over 100 prominent clinical experts and researchers. All are at the forefront of contributing new knowledge to enable us to provide better care for those seeking support for their shoulder problem. The team also comprises the vo...
Multidisciplinary Aspects of Design
This open access book gathers the contributions from the Design! OPEN International Conference, held in Parma, Italy in May 2022. The conference explored the multidisciplinary aspects of design starting from its dimensions: objects (design as focused on the object, on its functional and symbolic dimension, and at the same time on the object as a tool for representing cultures), processes (the designer’s self-reflective moment which is focused on the analysis and on the definition of processes in various contexts, spanning innovation, social engagement, reflection on emergencies or forecasting), experiences (design as a theoretical and practical strategy aimed at facilitating experiential interactions among people, people and objects or environments), and narratives (making history, representing through different media, archiving, narrating, and exhibiting design). The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaboration among different specialists.
Pediatrics in Systemic Autoimmune Diseases
Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.
