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Biology of Brain Disorders
Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking a...
Medicinal Cannabis: Evolution of Therapeutic Use, Future Approaches and Other Implications, Volume II
This Research Topic is the second volume of its kind. Please see the publications of the first collection here. Cannabis has been used in even the oldest traditional medicines available. In the last century, somewhat negative attention has prevailed when it comes to the psychotropic and addictive effects and abuse potential; for this reason Cannabis has been banned and is illegal in many countries. In recent years, however, there has been a more in-depth evaluation of the legalization of cannabinoids for medical use in several countries following heightened media attention and reports of effectiveness, although not always thoroughly backed up by scientific evidence. In fact, up to now the re...
In vivo Models for Drug Discovery
This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, incl...
Jesuit Superior General Luis Martín García and His Memorias
In Jesuit Superior General Luis Martín García and His Memorias, David Schultenover presents an account and interpretation of Martín’s memoir covering most of his sixty years, including candid reflections on church-state events and his personal life.
