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The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolle...
Lists for 19 include the Mathematical Association of America, and 1955- also the Society for Industrial and Applied Mathematics.
This pocket-sized book is designed to provide up-to-date information for the general paediatrican and paediatric nephrologist, including advice on care of emergencies, chronic disorders and covering common and rare conditions. It is highly relevant for the day-to-day care of patients on the ward or in the outpatient clinic.
This book presents advanced research studies on the topic of artificial intelligence as a component of social and economic relations and processes. It gathers research papers from the International Research-to-Practice Conference “The 21st Century from the Positions of Modern Science: Intellectual, Digital and Innovative Aspects” (May 23–24, 2019, Nizhny Novgorod, Russia) and the International Research-to-Practice Conference “Economics of Pleasure: a Science of Enjoying Economic Activities” (October 3–5, 2019, Prague, Czech Republic). Both conferences were organized by the Autonomous Non-Profit Organization “Institute of Scientific Communications” (Volgograd). What sets this ...
This book is the result of recent research by contemporary scientists on topics which were discussed at the conference of the same name in Volgograd, Russia in April 2017. The global economic system is currently in a stage of active formation and development: its boundaries and conditions of existence are constantly changing, which is accompanied by crises that influence the economic systems of its member countries. In order to solve problems emanating from global economic crises, a new direction was formed in modern science – global crisis management. Development of this direction requires the formation of the accompanying categorical apparatus, the development of a corresponding scientific and methodological basis, and the engagement in extensive practical research.
Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disorder caused by autoantibodies against post-synaptic proteins at the neuromuscular junction. These antibodies mostly attack the acetylcholine receptor (AChR), the muscle-specific kinase (MuSK), and the low-density lipoprotein-related protein 4 (LRP4). The main clinical characteristic of the disease is the presence of fluctuating fatigable muscle weakness involving the extraocular, facial, bulbar, respiratory, cervical, and proximal limb muscles. It is known that the thymus has an important role in the pathophysiology of the disease, and some patients associate a thymoma.