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Tuberous Sclerosis Complex
The only comprehensive overview of the molecular basis and clinical features of the genetic disorder tuberous sclerosis, which affects approximately 50,000 people in the US alone. Special focus is placed on novel insights into the signal transduction pathways affected by the disease as well as genotype phenotype correlations, while existing and potential therapies are also discussed in depth. The editors are leading experts in research and treatment of the disease as well as the Vice President of the Tuberous Sclerosis Alliance, the only voluntary health organization for TSC in the US.
Pediatric Cancer, Volume 3
Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy fac...
Global Perspectives on Green Business Administration and Sustainable Supply Chain Management
Heavy industrialization in the past few decades has caused several global environmental issues including poor air quality, climate change, and outdoor air pollution-related diseases. As such, consumer pressure coupled with strict governmental policies have influenced firms to adopt and implement green practices in their supply chain and business operations in order to improve socio-environmental sustainability. Global Perspectives on Green Business Administration and Sustainable Supply Chain Management is an essential reference book that discusses innovative green practices including recycling, remanufacturing, reduction in waste and adoption of renewable energy in manufacturing. It also examines environmentally friendly policies that have been adopted by many European and Western countries. Featuring coverage on a broad range of topics such as energy analysis, environmental protections, and logistics development, this book is ideally designed for managers, operations managers, executives, manufacturers, environmentalists, researchers, industry practitioners, academicians, and students.
Biology of seizures susceptibility in developement brain
Underling biology that governs the age-dependent seizure susceptibility is a new, exciting research field for every pediatric epileptologists and developmental nouroscientists. From daily practice, clinicians are well aware about a close correlation between the degree of seizure susceptibility and age of the individual. Pathophysiological mechanisms involved are multiplex, including race/gender nutrition, receptors/ion channels, dysgenesis, pharmacokinetics of AEDs, acute illnesses/inflammation and many others. In this book, the top-ranked experts contributed their original papers dealing with the cutting edge of knowledge in various aspects of underlying biology. Each article presents a comprehensive review of the subjects, guiding the readers to better understanding the contemporary status of achievements in this challenging research field.
