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More than 10 years have passed since the memorable symposium on "Myocardial Contractility," edited by R. D. Tanz, F. Kavaler and J. Roberts (New York and London, Academic Press, 1967). PathogeneSis of myocardial failure still involves many questions. The latest scien tific findings on fundamentals of myocardial contraction encouraged us to organize this international symposium held in Rottach-Egern at Tegernsee (Germany), June 17 to 19, 1976 sponsored by the European Society of Cardio~ogy. It seemed appropriate to assemble prominent workers in this field in an attempt to correlate their respective in formation on cardiac function. In this connection it must be remembered that our present und...
Primary myocardial disease, nowadays referred to as congestive or, more re cently, dilating cardiomyopathy, comprises disorders of varied etiology. Most oftenly the pathogenetic mechanism or causative agent remains unknown. The significance of inflammatory processes, i.e. myocarditis in a wider sense as the etiologic factor has been debated for many years. In a few instances, especially in children and newborns viral infections can be incriminated. In adults this etiology can be ascertained only in rare instances. And it has remained entirely uncertain if, or under which circumstances, and how often virus myocarditis can lead to a chronic disorder of the heart, namely dilated cardiomyopathy....
It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a ...
Microcirculation is a rather new field which has been of predominant interest to basic scientists, linking togeth~r technical, hemodynamic, and biochemical aspects. The fmdings elaborated, however, are not only of theoretical interest, but bear in addition great clinical implications. In clinical cardiology this became quite evident by the use of tracers in order to study myocardial perfuSion and by the deSCription of certain clinical entities - such as angina with normal coro nary arteries - which are best explained by "disturbed microcirculation". With respect to this new developing theoretical and clinical field of cardiac microcirculation it was the aim of the Microcirculation Working Gr...
The papers presented at the Fifth International Symposium on Heart Valves and published in this volume discuss clinical experience with heart valve replacement in pediatric patients, in adults (age 65 and younger), and in the elderly (age 66 and older). Special considerations in heart valve replacement, such as valve selection, reoperation, results of double valve implantation, quality of life, and the use of valved conduits are also included. Finally, long term clinical follow-up with the ST. JUDE MEDICAL® heart valve, giving 7- and 8-year data is discussed. HEART VALVE REPLACEMENT IN PEDIATRIC PATIENTS Anticoagulation Anticoagulation in children is a difficult and interesting problem. Thr...
First described in 1907 by Schicke but recognized as a clinical entity only as recently as 1958, when Teare published the pathologic findings in patients with hypertrophic cardiomyopathy (HeM), an explosion of knowledge about this fascinating disease has occurred, which has caused a profound evolution of our understanding of its broad pathophysiologic and clinical spectrum. Progress has been particularly rapid in the past few years when M-mode echocardiography, and more recently 2-dimen sional echocardiography have been applied to the study ofHCM. In addition to new insights as to what the disease is, there has been enormous progress concerning its treatment, with the application of beta-adrenergic blocking agents and surgical relief of left ventricular outflow tract obstruction. Although these approaches have led to great strides in the symptomatic control of the disease, many patients' symptoms have remained refactory to medical and surgical therapy. Most discouragingly, sudden death still occurs, even in patients on large doses of beta-blocking agents and in patients who have had surgical relief of left ventricular outflow tract obstruction.
First multi-year cumulation covers six years: 1965-70.
Once in four years, cardiologists of the world united into the International Society and Federation of Cardiology corne together to discuss the most pressing problems of cardiovascular pathology, sum up the accomplishments of the intervening years, and set directions for future research and exploitation of the existing knowledge. Not too much time passed since the I Paris Congress of International Foundation of Cardiology in 1950, but since then we have been witnessing a real information explosion. Extraordinary amounts of new knowledge, accumulated during the past three decades, has revolutionized our understanding of major cardiovascular diseases as well as approach to their treatment and ...
This book provides a modern survey on the pathophysiological and clinical implications of the most frequent forms of Car- diomyopathies, including diagnostic tools and new pharmaco- logical therapeutical approaches. An interesting additional aspect is the new data on immunology on dilated cardiomyo- mypathies and sudden death in children as well as heart transplantation as ultimum rationale of treatment.