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Current knowledge concerning both morphological and functional cryptorchid-related alterations in the various testicular compartments is summarized in this valuable new publication. Damage to the germinal epithelium and resulting infertility in both humans and experimental animals as well as the degree of damage to the different stages of germ cell development is discussed. In addition, information concerning hormonal therapy and orchidopexy to reverse cryptorchid-related damage is provided. Morphological alterations in Sertoli and Leydig cells is discussed in terms of cellular hypertrophy and hyperplasia, alterations in organelle number and characteristics as well as changes in cell-cell junctional complexes. Changes in Sertoli cell and Leydig cell function, including gonadotropin binding, steroidogenesis and other metabolic alterations is also outlined,as well as the influence of altered testicular function on subsequent hypothalamic-pituitary changes. Vascular disruption, the potential role of paracrine substances and direct thermal damage, all of which may be responsible for the resulting detrimental changes in one or more testicular compartments, are considered.
Pharmacology, Biology, and Clinical Applications of AndrogensCurrent Status and Future Prospects Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler,Ronald S. Swerdloff, Christina Wang, and Chuck Kelly As agents that affect the male primary and accessory sex organs,androgens--particularly the hormones testosterone andandrosterone--play a critical role in the development,functionality, and overall health of the male reproductive system.However, since androgens also have far-ranging effects onmetabolism, neurological activity, and behavior, scientistsexploring the contraceptive or therapeutic potential of androgensneed reliable, up-to-date information on the complex biologicalac...
Bieten Sie Ihren Patienten eine kompetente und überzeugende Gesundheitsberatung. Interdisziplinär und umfassend: - Alle typischen Beschwerden und Erkrankungen des Mannes - Prävention und Therapie-Praxis - Anti-Aging-Beratung - Direkt umsetzbare Tipps erfahrener Kliniker - Optimlae Organisation einer Gesundheitsberatung Ein vielseitiges neues Arbeitsfeld, auch interessant im Hinblick auf Selbstzahlerleistungen.
This resource brings you clear, unambiguous summaries of only the essentials of internal medicine. Ten parts cover the major organ systems and disciplines of internal medicine. Each part provides you with concise yet well-rounded descriptions of specific disease entities and clinical problems.