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The Functional Nucleus
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
Natural Product Extraction
Natural products are used by the food, pharmaceutical and cosmetics industries, and extraction technologies and potential applications for plant extracts are of interest to many industrial sectors. Extraction of natural products in an economic and environmentally friendly way is of high importance to all industries involved. The second edition of this book presents an updated, holistic, in-depth view of the more environmentally benign techniques available for the extraction of natural products, along with their newest applications and case studies. Conventional and emerging extraction techniques are discussed in detail. New topics include enzymes, pulsed electric energy, and on-line/in-line analysis. Written for academics and industrialists working in both natural product extraction and green chemistry, this new edition provides a valuable update on current trends in the field.
Multiple Sclerosis
The thoroughly revised and updated fourth edition of the classic Multiple Sclerosis: The Questions You Have, The Answers You Need continues to be the definitive guide for everyone concerned with this diseaseOCothose who have MS, those who share their lives with someone who has it, and all healthcare professionals involved with its management. It covers a wide range of topics in an accessible question and answer format that allows people to easily find the information they need."
Intratumor Diversity and Clonal Evolution in Cancer
This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise
Cancer Stem Cell Resistance to Targeted Therapy
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorati...
Trends in Stem Cell Proliferation and Cancer Research
The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance
Drug Discovery and Design Using Natural Products
Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural ...
Stem Cells and Cancer Stem Cells, Volume 5
It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells...
