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Management of Leg Ulcers
Chronic leg ulcers affect approximalety 1% of the adult population in industrial countries. They cause major disability and their enormous socioeconomic impact is still underestimated. This volume provides comprehensive information on the assessment and treatment of leg ulcers. Different aspects of venous leg ulcers like epidemiology, examination with Doppler and duplex sonography, venography, functional assessments as well as the most common modern classifications are recapitulated. Also, conservative treatment methods such as compression therapy, mobilization of the ankle joint and lymph drainage or different surgical techniques for recalcitrant venous ulcers are discussed. The chapters dealing with diabetic foot ulcers give a general outlook including patient instruction, orthopedic footwear and podiatric care along with management of the diabetic foot infection, and the indications for orthopedic and vascular interventions. General practitioners, internists, surgeons, dermatologists, as well as nurses, podiatrists, and physiotherapists will find this publication an indispensable summary on the state of the art in the management of chronic leg ulcers.
Logic, Language, Information and Computation
Edited in collaboration with FoLLI, the Association of Logic, Language and Information, this book constitutes the 4th volume of the FoLLI LNAI subline; containing the refereed proceedings of the 16h International Workshop on Logic, Language, Information and Computation, WoLLIC 2009, held in Tokyo, Japan, in June 2009. The 25 revised full papers presented together with six tutorials and invited talks were carefully reviewed and selected from 57 submissions. The papers cover some of the most active areas of research on the frontiers between computation, logic, and linguistics, with particular interest in cross-disciplinary topics. Typical areas of interest are: foundations of computing and programming; novel computation models and paradigms; broad notions of proof and belief; formal methods in software and hardware development; logical approach to natural language and reasoning; logics of programs, actions and resources; foundational aspects of information organization, search, flow, sharing, and protection.
Fundamentals of Gifted Education
The field of gifted education is characterized by a confusing array of perspectives concerning such fundamental issues as definition, philosophy, curriculum, social and emotional development, and underserved populations. The mission of this book is to provide a coherent framework that instructors and service providers can use in planning effective programs, providing appropriate counseling services, and evaluating programs for the gifted. Most sections are organized around fundamental issues confronting the field and follow a common structure: an introductory chapter that provides historical and theoretical background and organizing questions followed by several point-of-view chapters writte...
Chemical Mutagens
New developments in the study of environmental mutagens continue to evolve in this rapidly emerging field. In Volume 7 of Chemical Mutagens, we have focused on various new techniques for the detection of genetic damage in somatic cells and germ cells of mammals and the use of lower eukaryotic microorganisms to detect aneuploidy as well as other types of genetic damage. Attention has also been given to the role of in vitro metabolic activation as a mechanism for modifying the genetic effects of different environmental chemicals. In a chapter on compar ative mutagenesis, reaction kinetics and their relationship to the mu tagenic action of monofunctional alkylating agents in higher eukaryotic o...
OWL: Experiences and Directions – Reasoner Evaluation
This book constitutes the thoroughly refereed conference proceedings of the 13International Workshop on OWL: Experiences and Directions, OWLED 2016, and the 5th International Workshop on OWL: Reasoner Evaluation, ORE 2016, held in Bologna, Italy in November 20, 2016. The Workshops were co-located with the 20th International Conference on Knowledge Engineering and Knowledge Management, EKAW 2016. The 11 revised full papers, 3 short paper and one invited talk presented were carefully reviewed and selected from 27 initial submissions. The papers are trying to bridge the gap between ontology engineering practices and software engineering with the aim of describing reuse methods employed throughout the ontology development cycle; modeling/terminological decisions, alignment and comparison between ontologies, how ontologies are stored, versioned, distributed and consumed over the Web. Chapter “Use Cases and Suitability Metrics for Unit Ontologies” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Advances in Heterocyclic Chemistry
Advances in Heterocyclic Chemistry, Volume 140 is the latest release in this definitive series in the field of heterocyclic chemistry, one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include The chemistry of citrazinic acid (2,6-dihydroxyisonicotinic acid), Aza-Diels-Alder Reaction in the Synthesis of Tetrahyroquinoline Structures, and more. Add...
G Protein-Coupled Receptors in Energy Homeostasis and Obesity Pathogenesis
Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans. - Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs - Chapters are written by leading experts
Tissue Engineering Methods and Protocols
In recent years, the field of tissue engineering has begun, in part, to c- lesce around the important clinical goal of developing substitutes or repla- ments for defective tissues or organs. These efforts are focused on many tissues including skin, cartilage, liver, pancreas, bone, blood, muscle, the vascu- ture, and nerves. There is a staggering medical need for new and effective treatments for acquired as well as inherited defects of organs/tissues. Tissue engineering is at the interface of the life sciences, engineering, and clinical medicine and so draws upon advances in cell and molecular biology, mate- als sciences, and surgery, as well as chemical and mechanical engineering. Such an interdisciplinary field requires a broad knowledge base as well as the use of a wide assortment of methods and approaches. It is hoped that by bringing together these protocols, this book will help to form connections - tween the different disciplines and further stimulate the synergism underlying the foundation of the tissue engineering field.
