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Leishmaniasis
Leishmaniasis is a major global health challenge, affecting approximately 12 million of the poorest people in 100 countries. It is a deforming and fatal disease in the visceral form. Therapies for leishmaniasis are numerically restricted, basically consisting of the administration of miltefosine, pentavalent antimonials, amphotericin B, or pentamidine. This is an important vulnerability against therapy efficiency that must be overcome by the scientific community. This book discusses important aspects of the disease, such as treatment, epidemiology, and molecular and cell biology. The information contained herein is important for young researchers as they seek to develop safe and effective treatments for this neglected tropical disease.
Use of Cell Biology to Identify Cellular Targets in Drug Development Process Against Leishmania Sp
Leishmaniasis is one of the most important neglected tropical diseases. The chemotherapy for its treatment uses very toxic compounds with a low efficacy rate. Thus, there is an urgent need to develop new chemotherapeutic agents to help countries control this devasting disease. In drug development, different approaches can be used to identify potential cellular targets that allow us to understand better the cell biology of eukaryotic cells. Several groups are dedicated to studying new molecules, searching for promising candidates against Leishmania. Different techniques have been used to characterize the cell biology, biochemistry, and molecular biology alterations induced by the treatments, trying to understand the mechanisms of action. The main goal of this chapter is to describe an overview of the literature exploring the several studies published about the chemotherapy of anti-Leishmania concerning the mechanisms of action of different classes of molecules or therapeutic alternatives.
Diplomatic List
Directory of foreign diplomatic officers in Washington.
Educação Física, Práticas Corporais e Saúde Vivências de Extensão em Instituições de Ensino Público da Bahia
Este ebook apresenta ao longo de seus capítulos, relatos e reflexões de vivências relacionadas à prática de atividade física, práticas esportivas e corporais, em projetos de extensão realizados em duas instituições de ensino público da Bahia: no âmbito do ensino técnico e tecnológico no IF Baiano; e no ensino superior, na Universidade do Estado da Bahia. O livro foi dividido em dois momentos, sendo o primeiro direcionado para reflexão das práticas extensionistas realizadas até o final do ano de 2019, antes da pandemia mundial pela Covid-19. Nessa etapa foram discutidos o valor da extensão para a comunidade, em que a instituição está inserida, assim como a relevância da ...
Bulletin
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Intelligent Systems
The three-volume set LNAI 14195, 14196, and 14197 constitutes the refereed proceedings of the 12th Brazilian Conference on Intelligent Systems, BRACIS 2023, which took place in Belo Horizonte, Brazil, in September 2023. The 90 full papers included in the proceedings were carefully reviewed and selected from 242 submissions. They have been organized in topical sections as follows: Part I: Best papers; resource allocation and planning; rules and feature extraction; AI and education; agent systems; explainability; AI models; Part II: Transformer applications; convolutional neural networks; deep learning applications; reinforcement learning and GAN; classification; machine learning analysis; Part III: Evolutionary algorithms; optimization strategies; computer vision; language and models; graph neural networks; pattern recognition; AI applications.
Direitos em Transformação
Este é um compilado de resumos das pesquisas desenvolvidas por alunos do curso de Direito da Universidade Estadual de Santa Cruz (UESC), sob a orientação da professora Me. Catrine da Mata, com a colaboração da pesquisadora Me. Kalita Paixão. As investigações abordam temas contemporâneos e desafiadores no campo do Direito Empresarial e do Direito do Trabalho, refletindo as transformações recentes no mercado de trabalho e as inovações legislativas que impactam diretamente as relações laborais no Brasil.
