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Leishmaniasis
Leishmaniasis is a major global health challenge, affecting approximately 12 million of the poorest people in 100 countries. It is a deforming and fatal disease in the visceral form. Therapies for leishmaniasis are numerically restricted, basically consisting of the administration of miltefosine, pentavalent antimonials, amphotericin B, or pentamidine. This is an important vulnerability against therapy efficiency that must be overcome by the scientific community. This book discusses important aspects of the disease, such as treatment, epidemiology, and molecular and cell biology. The information contained herein is important for young researchers as they seek to develop safe and effective treatments for this neglected tropical disease.
Use of Cell Biology to Identify Cellular Targets in Drug Development Process Against Leishmania Sp
Leishmaniasis is one of the most important neglected tropical diseases. The chemotherapy for its treatment uses very toxic compounds with a low efficacy rate. Thus, there is an urgent need to develop new chemotherapeutic agents to help countries control this devasting disease. In drug development, different approaches can be used to identify potential cellular targets that allow us to understand better the cell biology of eukaryotic cells. Several groups are dedicated to studying new molecules, searching for promising candidates against Leishmania. Different techniques have been used to characterize the cell biology, biochemistry, and molecular biology alterations induced by the treatments, trying to understand the mechanisms of action. The main goal of this chapter is to describe an overview of the literature exploring the several studies published about the chemotherapy of anti-Leishmania concerning the mechanisms of action of different classes of molecules or therapeutic alternatives.
Biological and Pharmacological Activity of Plant Natural Compounds
Phytotherapy is probably the oldest form of medicine; however, it represents a new therapeutic tool for healthcare workers. Indeed plants are an infinite source of novel molecules, with countless possible combinations. This collection of articles (a Special Issue from Molecules) brings together the most up-to-date studies on the use of plant-derived compounds, ranging from their anti-inflammatory, antioxidant, and anticancer effects to the revision of the prominent literature.
Anais
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Beleza Negra
Best-seller internacional com mais de cinquenta milhões de cópias vendidas. Beleza Negra é um drama sensível que conscientiza sobre o bem-estar animal enquanto educa gentilmente acerca de empatia e respeito ao próximo. Após uma infância feliz, um jovem cavalo de coração nobre descobre que nem todos os humanos são bons. A cada novo dono, Beleza Negra se depara com o carinho, o abandono, a abundância e os maus-tratos. Publicado em 1877, Beleza Negra é um clássico imortal para tocar o coração dos leitores.
O Tripeiro
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Progress in Artificial Intelligence
This book constitutes the refereed proceedings of the 19th EPIA Conference on Artificial Intelligence, EPIA 2019, held in Funchal, Madeira, Portugal, in September 2019. The 119 revised full papers and 6 short papers presented were carefully reviewed and selected from a total of 252 submissions. The papers are organized in 18 tracks devoted to the following topics: AIEd - Artificial Intelligence in Education, AI4G - Artificial Intelligence for Games, AIoTA - Artificial Intelligence and IoT in Agriculture, AIL - Artificial Intelligence and Law, AIM - Artificial Intelligence in Medicine, AICPDES - Artificial Intelligence in Cyber-Physical and Distributed Embedded Systems, AIPES - Artificial Int...
The Left Divided
The Left Divided argues that the strength and orientation of the far left is an important and overlooked determinant of social protection outcomes. To demonstrate the counterintuitive effects of having the far-left control significant political resources, the book combines in-depth case studies of Iberia with cross-national analysis of OECD countries.
Diario Oficial
Laws, decrees, and administrative acts of government.
