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The Opiate Receptors
The growth of the opiate field over the past decade has been enor mous. Initial interest focused upon the strategic clinical impor tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi gators in almost all areas of neuroscience as well as pharmacol ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have ...
The Opiate Receptors
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The Opiate Receptors
This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
Apprentices to Genius: A tribute to Solomon H. Snyder
Apprentices to Genius: A tribute to Solomon H. Snyder, a volume in the Advances in Pharmacology series, presents a tribute to Dr. Solomon H. Snyder, highlighting chapters submitted from a broad range of his students. It covers many different areas of neuroscience and pharmacology, with this volume exploring how receptor binding and drug discovery, the emerging role of glutamate in the pathophysiology of mental illness, nitric oxide signaling in neurodegeneration and cell death, carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets, the regulation of mitochondrial functions by TSPO, clozapine and its translational investigation, and more. - Includes the authority and expertise of leading contributors in pharmacology as sourced from an international board of authors - Presents the latest release in the Advances in Pharmacology series - Provides a tribute to Dr. Solomon H. Snyder, highlighting chapters submitted from a broad range of his students
Sigma Proteins: Evolution of the Concept of Sigma Receptors
Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recen...
Substance Use Disorders
The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.
Synaptic Modulators
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Science and Psychiatry
Solomon Snyder has been instrumental in the establishment of modern psychopharmacology -- as a pioneer in the identification of receptors for neurotransmitters and drugs and in the explanation of the actions of psychotropic agents. Science and Psychiatry is a collection of some of his best scientific papers, publications ranging over forty years that represent important advances in psychopharmacology and molecular biology. Audacious and unanticipated when they first appeared, these papers opened up new areas of understanding and revolutionized the modern study of the brain. Republished here, they show why fundamental research into the "messengers of the mind" is as essential for clinicians a...
The Correspondence of Boris Pasternak and Olga Freidenberg, 1910-1954
Letters exchanged between Pasternak and his cousin chronicle their personal lives and the suffering of Russia during the Stalin era.
Social Control and Multiple Discovery in Science
Recognition for accomplishment is a major institutional reward in the scientific community, thus regulating disputes over credit for discovery, can be viewed as an important problem in social control. Cozzens examines a well-known dispute — one that took place with the discovery of the opiate receptor in neuropharmacological research. The issues Cozzens discusses — priority disputes, social control, and norms and morals — are important throughout the sciences; they are crucial factors in the lives of scientists, the functioning of scientific communities, and the day-to-day operations of scientific organizations.
