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The Science of Reconstructive Transplantation
This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book. The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.
Hand Transplantation, An Issue of Hand Clinics - E-Book
The History and Evolution of Hand Transplantation, World Experience After More Than a Decade of Clinical Hand Transplantation, How to Establish a Hand Transplant Program, Recipient Selection – Who is the Right Candidate for Hand Transplantation? Donor-related Issues in Hand Transplantation, Surgical and Technical Aspects of Hand Transplantation – Is it Just Another Replant? Functional Outcome After Hand Transplantation – What can be Achieved? Strategies to Enhance Nerve Regeneration, Immunosuppressive Protocols and Immunological Challenges Related to Hand Transplantation, Acute and Chronic Rejection in Hand Transplantation – What have we Learned? Favoring the Risk Benefit Balance for Hand Transplantation – The Pittsburgh Approach Ethical, Financial and Policy Considerations of Hand Transplantation
From Auto- to Allotransplantation
This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center fo...
Teaching Ethics in Organ Transplantation and Tissue Donation
"Organ transplantation is a thrilling new option for modern surgery giving hope for chronically ill patients, and, at the same time, stirring controversial ethical questions on human identity and the meaning of the human body. Being a global and transnational endeavor, organ transplantation raises universal ethical concerns and, yet, has to be adapted to culturally mediated believes. In this book, 30 case studies collected from all over the world illustrate the range of global and local, ethical, social, and cultural problems associated with this new form of treatment. Together with a list of relevant movies, the collection provides a unique resource for ethics education in medicine, health care, philosophy, and religious studies. The authors have completed the teaching material by a systematic introduction into the field of transplantation ethics"--Introduction
A Revised Consent Model for the Transplantation of Face and Upper Limbs: Covenant Consent
This book supports the emerging field of vascularized composite allotransplantation (VCA) for face and upper-limb transplants by providing a revised, ethically appropriate consent model which takes into account what is actually required of facial and upper extremity transplant recipients. In place of consent as permission-giving, waiver, or autonomous authorization (the standard approaches), this book imagines consent as an ongoing mutual commitment, i.e. as covenant consent. The covenant consent model highlights the need for a durable personal relationship between the patient/subject and the care provider/researcher. Such a relationship is crucial given the recovery period of 5 years or mor...
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Textbook of Organ Transplantation Set
Brought to you by the world’s leading transplantclinicians, Textbook of Organ Transplantation provides acomplete and comprehensive overview of modern transplantation inall its complexity, from basic science to gold-standard surgicaltechniques to post-operative care, and from likely outcomes toconsiderations for transplant program administration, bioethics andhealth policy. Beautifully produced in full color throughout, and with over 600high-quality illustrations, it successfully: Provides a solid overview of what transplantclinicians/surgeons do, and with topics presented in an order thata clinician will encounter them. Presents a holistic look at transplantation, foregrounding theinterrel...
Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the tran...
