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Introduction to Material and Energy Balances
A thorough introduction to balance equation concepts. Geared for the course offered to chemical engineering majors in their sophomore year. Develops a framework for the analysis of flowsheet problem information with extensive use of degree-of-freedom analysis. Presents systematic approaches for manual and computer-aided solution of full scale balance problems. Provides a detailed development of the structure, properties, and interrelationships of species and element balances based on the algebraic view of reaction-stoichiometry and the rate of reaction concept.
Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture
Covers a widespread view of Quality by Design (QbD) encompassing the many stages involved in the development of a new drug product. The book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing processes and provides the underpinnings for a science-based regulation of the pharmaceutical industry. Edited by the three renowned researchers in the field, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture guides pharmaceutical engineers and scie...
Batch Processing Systems Engineering
Batch chemical processing has in the past decade enjoyed a return to respectability as a valuable, effective, and often preferred mode of process operation. This book provides the first comprehensive and authoritative coverage that reviews the state of the art development in the field of batch chemical systems engineering, applications in various chemical industries, current practice in different parts of the world, and future technical challenges. Developments in enabling computing technologies such as simulation, mathematical programming, knowledge based systems, and prognosis of how these developments would impact future progress in the batch domain are covered. Design issues for complex unit processes and batch plants as well as operational issues such as control and scheduling are also addressed.
Engineering Optimization
The classic introduction to engineering optimization theory and practice--now expanded and updated Engineering optimization helps engineers zero in on the most effective, efficient solutions to problems. This text provides a practical, real-world understanding of engineering optimization. Rather than belaboring underlying proofs and mathematical derivations, it emphasizes optimization methodology, focusing on techniques and stratagems relevant to engineering applications in design, operations, and analysis. It surveys diverse optimization methods, ranging from those applicable to the minimization of a single-variable function to those most suitable for large-scale, nonlinear constrained prob...
Continuous Pharmaceutical Processing
Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuou...
34th European Symposium on Computer Aided Process Engineering /15th International Symposium on Process Systems Engineering
The 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, contains the papers presented at the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. Presents findings and discussions from the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event
Continuous Manufacturing for the Modernization of Pharmaceutical Production
On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.
21st European Symposium on Computer Aided Process Engineering
The European Symposium on Computer Aided Process Engineering (ESCAPE) series presents the latest innovations and achievements of leading professionals from the industrial and academic communities. The ESCAPE series serves as a forum for engineers, scientists, researchers, managers and students to present and discuss progress being made in the area of computer aided process engineering (CAPE). European industries large and small are bringing innovations into our lives, whether in the form of new technologies to address environmental problems, new products to make our homes more comfortable and energy efficient or new therapies to improve the health and well being of European citizens. Moreover, the European Industry needs to undertake research and technological initiatives in response to humanity's "Grand Challenges," described in the declaration of Lund, namely, Global Warming, Tightening Supplies of Energy, Water and Food, Ageing Societies, Public Health, Pandemics and Security. Thus, the Technical Theme of ESCAPE 21 will be "Process Systems Approaches for Addressing Grand Challenges in Energy, Environment, Health, Bioprocessing & Nanotechnologies."
Optimization of Pharmaceutical Processes
Optimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.
Advances in Energy Systems Engineering
This book provides a scientific framework for integrated solutions to complex energy problems. It adopts a holistic, systems-based approach to demonstrate the potential of an energy systems engineering approach to systematically quantify different options at various levels of complexity (technology, plant, energy supply chain, mega-system). Utilizing modeling, simulation and optimization-based frameworks, along with a number of real-life applications, it focuses on advanced energy systems including energy supply chains, integrated biorefineries, energy planning and scheduling approaches and urban energy systems. Featuring contributions from leading researchers in the field, this work is useful for academics, researchers, industry practitioners in energy systems engineering, and all those who are involved in model-based energy systems.
