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Exosomes and MicroRNAs in Biomedical Science
MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typic...
Nanotechnology for Bioengineers
Nanotechnology is an interdisciplinary field that is rapidly evolving and expanding. Significant advancements have been made in nanotechnology-related disciplines in the past few decades and continued growth and progression in the field are anticipated. Moreover, nanotechnology, omnipresent in innovation, has been applied to resolve critical challenges in nearly every field, especially those related to biological technologies and processes. This book, used as either a textbook for a short course or a reference book, provides state-of-the-art analysis of essential topics in nanotechnology for bioengineers studying and working in biotechnology, chemical/biochemical, pharmaceutical, biomedical, and other related fields. The book topics range from introduction to nanotechnology and nanofabrication to applications of nanotechnology in various biological fields. This book not only intends to introduce bioengineers to the amazing world of nanotechnology, but also inspires them to use nanotechnology to address some of the world's biggest challenges.
Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy
Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.
Fast Quantitative Magnetic Resonance Imaging
Among medical imaging modalities, magnetic resonance imaging (MRI) stands out for its excellent soft-tissue contrast, anatomical detail, and high sensitivity for disease detection. However, as proven by the continuous and vast effort to develop new MRI techniques, limitations and open challenges remain. The primary source of contrast in MRI images are the various relaxation parameters associated with the nuclear magnetic resonance (NMR) phenomena upon which MRI is based. Although it is possible to quantify these relaxation parameters (qMRI) they are rarely used in the clinic, and radiological interpretation of images is primarily based upon images that are relaxation time weighted. The clini...
Landscape and Change in Early Medieval Italy
An innovative environmental history of the chestnut tree and what it can tell us about the medieval history of Italy.
3D Electro-Rotation of Single Cells
Dielectrophoresis microfluidic chips have been widely used in various biological applications due to their advantages of convenient operation, high throughput, and low cost. However, most of the DEP microfluidic chips are based on 2D planar electrodes which have some limitations, such as electric field attenuation, small effective working regions, and weak DEP forces. In order to overcome the limitations of 2D planar electrodes, two kinds of thick-electrode DEP chips were designed to realize manipulation and multi-parameter measurement of single cells. Based on the multi-electrode structure of thick-electrode DEP, a single-cell 3D electro-rotation chip of "Armillary Sphere" was designed. The...
Dante and Renaissance Florence
Simon Gilson explores Dante's reception in his native Florence between 1350 and 1481. He traces the development of Florentine civic culture and the interconnections between Dante's principal 'Florentine' readers, from Giovanni Boccaccio to Cristoforo Landino, and explains how and why both supporters and opponents of Dante exploited his legacy for a variety of ideological, linguistic, cultural and political purposes. The book focuses on a variety of texts, both Latin and vernacular, in which reference was made to Dante, from commentaries to poetry, from literary lives to letters, from histories to dialogues. Gilson pays particular attention to Dante's influence on major authors such as Boccaccio and Petrarch, on Italian humanism, and on civic identity and popular culture in Florence. Ranging across literature, philosophy and art, across languages and across social groups, this study fully illuminates for the first time Dante's central place in Italian Renaissance culture and thought.
Laus Platonici Philosophi
This collection of essays honours Marsilio Ficino (1433-1499) as a Platonic philosopher. Ficino was not the first translator of Plato in the Renaissance, but he was the first to translate the entire corpus of Platonic works, and to emphasise their relevance for contemporary readers. The present work is divided into two sections: the first explores aspects of Ficino’s own thought and the sources which he used. The second section follows aspects of his influence in the sixteenth and seventeenth centuries. The papers presented here deepen and enrich our understanding of Ficino, and of the philosophical tradition in which he was working, and they offer a new platform for future studies on Ficino and his legacy in Renaissance philosophy. Contributors include: Unn Irene Aasdalen, Constance Blackwell, Paul Richard Blum, Stephen Clucas, Ruth Clydesdale, Brian Copenhaver, John Dillon, Peter J. Forshaw, James Hankins, Hiro Hirai, Sarah Klitenic Wear, David Leech, Letizia Panizza, Valery Rees, and Stéphane Toussaint.
