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Small Molecules in Oncology
This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.
Environmental Pollution and Remediation
This book presents state-of-the-art environmental remediation processes. Environmental protection and management is a global concern, especially in the context of industrial regions. Over the years, several conventional, engineering-based physicochemical decontamination methods have used in the remediation of polluted sites. However, these methods are expensive and have limited efficiency. Drawing on research and examples from around the world, this book offers a comprehensive review of and insights into green technologies and sustainable remediation alternatives. It discusses the emerging importance of nanotechnology, chemo and biosensors, indicator species, microbe-based remediation of organic compounds, and ex-situ remediation methods. Addressing the growing global need for a holistic overview of the environmental remediation of polluted sites, it will appeal to teachers, researchers, scientists, capacity builders, and policymakers. It also serves as additional reading material for undergraduate and graduate students of biotechnology and environmental sciences.
Chronic Graft Versus Host Disease
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Enforcing Privacy
This book is about enforcing privacy and data protection. It demonstrates different approaches – regulatory, legal and technological – to enforcing privacy. If regulators do not enforce laws or regulations or codes or do not have the resources, political support or wherewithal to enforce them, they effectively eviscerate and make meaningless such laws or regulations or codes, no matter how laudable or well-intentioned. In some cases, however, the mere existence of such laws or regulations, combined with a credible threat to invoke them, is sufficient for regulatory purposes. But the threat has to be credible. As some of the authors in this book make clear – it is a theme that runs thro...
12 Steps to Raw Foods
With eye-opening self-tests and questionnaires, this step-by-step guide will help you replace unhealthy eating patterns with a diet of fresh, raw foods Why do we overeat time and time again? Why do we make poor diet choices? Why is dieting so difficult? Using the latest scientific research and an open, conversational tone, 12 Steps to Raw Foods addresses these vital questions and explains the numerous benefits of choosing a diet of fresh—versus cooked—foods. But rather than simply praising the benefits of raw foods, this book offers helpful tips and coping techniques to form and maintain new, healthy patterns. Learn how to make a raw food restaurant card that makes dining with co-workers...
The Oxford Handbook of the Early Modern Sermon
The Oxford Handbook of the Early Modern Sermon is the first book to survey this rich new field for both students and specialists. It is divided into sections devoted to sermon composition, delivery, and reception; sermons in Scotland, Ireland, and Wales; English Sermons, 1500-1660; and English Sermons, 1660-1720.
Churches and Education
Brings together the work of a wide range of scholars to explore the history of churches and education.
