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Pemphigus and pemphigoid diseases: in memoriam Detlef Zillikens
Pemphigus and pemphigoid diseases are a heterogenous group of autoimmune blistering disorders (AIBD) characterized by tissue-bound and circulating autoantibodies against structural proteins of the desmosome and basement membrane zone of the skin and orifice-close mucosal tissues. While strong evidence has been provided that autoantibodies in AIBD are pathogenic, the exact mechanisms of how blister formation is mediated is very different between pemphigus and pemphigoid disorders and yet incompletely understood. Additionally, target antigens for the major AIBDs have already been identified on the molecular level. In contrast, diagnostic assays are not yet available for all autoantibody specif...
Porokeratosis Plantaris, Palmaris Et Disseminata Caused by Con- Genital Pathogenic Variants in the MVD Gene and Loss of Heterozygosity in Affected Skin
Abstract: Porokeratoses are a heterogeneous group of keratinization disorders. For linear porokeratosis and disseminated superficial actinic porokeratosis, a heterozygous pathogenic germline variant in a mevalonate pathway gene and a postzygotic second hit mutation present in affected skin have been shown to be the pathogenetic mechanism for the development of the lesions. However, the molecular mechanism leading to development of porokeratosis plantaris, palmaris et disseminata is not known. This study analysed a cohort of 4 patients with linear porokeratosis and 3 patients with porokeratosis plantaris, palmaris et disseminata, and performed mutation analyses of DNA extracted from blood sam...
Laser and IPL Technology in Dermatology and Aesthetic Medicine
The editors have gathered 15 laser experts from the United States, Europe and Asia to present the most up to date information in cutaneous laser surgery and intense pulsed light technologies. This innovative book describes new laser techniques (laserlipolysis, fractional photothermolysis, among others) and provides expert guidance on using lasers successfully in over 80 clinical indications.
Mosaicism in Human Skin
This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic ...
Neurocutaneous Disorders
Neurocutaneous syndromes and hemangiomas encompass a substantial proportion of congenital or hereditary disorders, and present themselves through variable clinical features. Though often complex and multi-systemic, these disorders can mostly be diagnosed by simple visual inspections and strong clinical expertise. The purpose of this book is to compile in a single volume a comprehensive review of the historical perspective, the clinical features, the current knowledge concerning the pathogenesis, and the diagnostic and therapeutic strategies associated with these challenging disorders. Strong emphasis throughout is given on the biochemical, molecular, and genetic basis of these syndromes. The international editorial team have drawn upon contributions from colleagues, and from fully referenced information from thousands of articles, thus providing the reader with an outstanding up-to-date resource for the diagnosis and treatment of neurocutaneous disorders.
Travellers' Health
Travellers' Health offers practical advice on preventing and coping with every health problem imaginable. Authoritatively written by over 70 experts, this book is essential reading for all travellers worldwide.
Nail Disorders
This book is designed to meet the need for a concise, easy-to-read text on how to approach and manage patients with nail diseases. The book opens with a description of nail anatomy and physiology, followed by a review of nail symptoms, divided according to the part of the nail apparatus involved. Non-invasive and invasive tools for the diagnosis of nail disorders are then described and insights provided into their appropriate use. Subsequent chapters review the various nail diseases, covering hereditary, traumatic, inflammatory, environmentally induced, drug-induced and neoplastic conditions as well as disorders due to systemic diseases. Informative high-quality illustrations are included for each disorder and boxes helpfully summarize the most important features, clues to diagnosis, necessary examinations, and treatments. Closing chapters address nail conditions in children and the elderly. Nail Disorders: A Practical Guide to Diagnosis and Management will be an invaluable, ready source of information for students in dermatology, clinical practitioners and podiatrists.
Veterinary Entomology
Although usually treated as unified subject, in many respects the two components of what is broadly described as 'medical and veterinary is usual, the term entomology is entomology' are clearly distinct. As used loosely here to refer to both insects and arachnids. In medical entomology blood-feeding Diptera are of paramount importance, primarily as vectors of pathogenic disease. Most existing textbooks reflect this bias. However, in veterinary entomology ectoparasites such as the mites, fleas or dipteran agents of myiasis assume far greater prominence and the most important effects of their parasitic activity may be mechanical damage, pruritus, blood loss, myiasis, hypersensitivity and derma...
