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Calcium plays an important role in a wide variety of biological processes. This divalent metal ion can bind to a large number of proteins; by doing so it modifies their biological activity or their stability. Because of its distinct che- cal properties calcium is uniquely suited to act as an on–off switch or as a light dimmer of biological activities. The two books entitled Calcium-Binding Protein Protocols (Volumes I and II) focus on modern experimental analyses and methodologies for the study of calcium-binding proteins. Both extracel- lar and intracellular calcium-binding proteins are discussed in detail. H- ever, proteins involved in calcium handling (e. g. , calcium pumps and calcium ...
This authoritative volume contains 179 chapters by international experts on recent developments in our understanding of amyloid proteins, protein folding disorders, and new and proposed clinical trials in amyloidosis. Topics include detection and characterization techniques; biological functions; genetics; disorders, diagnosis, and treatments, incl
Although infrared spectroscopy has been applied with success to the study of important biological and biomedical processes for many years, key advances in this vibrant technique have led to its increasing use, ranging from characterisation of individual macromolecules (DNA, RNA, lipids, proteins) to human tissues, cells and their components. Infrared spectroscopy thus has a significant role to play in the analysis of the vast number of genes and proteins being identified by the various genomic sequencing projects. Whilst this book gives an overview of the field it highlights more recent developments, such as the use of bright synchrotron radiation for recording infrared spectra, the developm...
This book presents the current state of research in information systems and digital transformation. Due to the global trend of digitalization and the impact of the Covid 19 pandemic, the need for innovative, high-quality research on information systems is higher than ever. In this context, the book covers a wide range of topics, such as digital innovation, business analytics, artificial intelligence, and IT strategy, which affect companies, individuals, and societies. This volume gathers the revised and peer-reviewed papers on the topic "Technology" presented at the International Conference on Information Systems, held at the University of Duisburg-Essen in 2021.
Between Hitler and Churchill exposes an unknown facet in the World War II history: the attempt of a senior official in the Polish government-in-exile to collude with the Third Reich and a successful British intelligence operation which thwarted this move in its infancy. This surprising and fascinating event is described through the personal stories of its two main protagonists, Polish Jews. One of them mediated the said Polish-German contacts, while the other assisted the British in capturing the mediator in the Middle East and murdering him there without trial. Although it reads like a historical thriller, the book is based on British, Polish, German and Russian diplomatic and intelligence reports, many of which are revealed and analyzed here for the first time.
The refereed proceedings of the 8th International Symposium on Spatial and Temporal Databases, SSTD 2003, held at Santorini Island, Greece in July 2003. The 28 revised full papers presented together with a keynote paper were carefully reviewed and selected from 105 submissions. The papers are organized in topical sections on access methods, advanced query processing, data mining and data warehousing, distance-based queries, mobility and moving points management, modeling and languages, similarity processing, systems and implementation issues.
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Imperial and Local Citizenship in the Long Second Century CE explores the significance of Roman citizenship in the long century before Caracalla's universal grant of citizenship in 212 CE. From this emerges a new portrait of the early Roman empire: an exclusive regime of citizenship persisted, in a context of remarkable political and cultural integration.