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Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow
Streptococcus pneumoniae is a major cause of community acquired pneumonia and septicaemia in humans. These diseases are frequently associated with thromboembolic cardiovascular complications. Pneumococci induce the exocytosis of endothelial Weibel-Palade Bodies and thereby actively stimulate the release of von Willebrand factor (VWF), which is an essential glycoprotein of the vascular hemostasis. Both, the pneumococcus induced pulmonary inflammation and the thromboembolytic complications are characterized by a dysbalanced hemostasis including a marked increase in VWF plasma concentrations. Here, we describe for the first time VWF as a novel interaction partner of capsulated and non-encapsula...
Mathematical Theory of Scattering Resonances
Scattering resonances generalize bound states/eigenvalues for systems in which energy can scatter to infinity. A typical resonance has a rate of oscillation (just as a bound state does) and a rate of decay. Although the notion is intrinsically dynamical, an elegant mathematical formulation comes from considering meromorphic continuations of Green's functions. The poles of these meromorphic continuations capture physical information by identifying the rate of oscillation with the real part of a pole and the rate of decay with its imaginary part. An example from mathematics is given by the zeros of the Riemann zeta function: they are, essentially, the resonances of the Laplacian on the modular...
1990 Proceedings
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Jahresbericht
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The Governor's Dilemma
The Governor's Dilemma develops a general theory of indirect governance based on the tradeoff between governor control and intermediary competence; the empirical chapters apply that theory to a diverse range of cases encompassing both international relations and comparative politics. The theoretical framework paper starts from the observation that virtually all governance is indirect, carried out through intermediaries. But governors in indirect governance relationships face a dilemma: competent intermediaries gain power from the competencies they contribute, making them difficult to control, while efforts to control intermediary behavor limit important intermediary competencies, including e...
