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Parasite Genomics Protocols
Parasite Genomics Protocols, Second Edition expands upon the previous edition with current, detailed methodologies that have been adapted to research parasites in the post genomic era. With new chapters on parasite studies, helminth pathogens, and protocols for undertaking other large-scale ‘omics’ methodologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Parasite Genomics Protocols, Second Edition offers a wide-ranging collection of diverse methods and protocols for further study into these unique organisms.
Pause and Effect
From its publication in 1992 Pause and Effect has become a cornerstone of the study of punctuation across the world. Described as 'magisterial' by Lynne Truss in her best-selling Eats, Shoots and Leaves, this book has stimulated interest and scholarly debates among writers, literary critics, philosophers, linguists, rhetoricians, palaeographers and all those who study the use of language. To celebrate this extraordinary achievement, Pause and Effect has been republished in September 2008, coinciding with the publication of the author's new work, Their Hands Before Our Eyes. The first part of Pause and Effect identifies the graphic symbols of punctuation and deals with their history. It cover...
Extracellular and Intracellular Signaling
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
The Neutral Theory of Molecular Evolution
Motoo Kimura, as founder of the neutral theory, is uniquely placed to write this book. He first proposed the theory in 1968 to explain the unexpectedly high rate of evolutionary change and very large amount of intraspecific variability at the molecular level that had been uncovered by new techniques in molecular biology. The theory - which asserts that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants - has caused controversy ever since. This book is the first comprehensive treatment of this subject and the author synthesises a wealth of material - ranging from a historical perspective, through recent molecular discoveries, to sophisticated mathematical arguments - all presented in a most lucid manner.
Statistical Methods in Molecular Evolution
In the field of molecular evolution, inferences about past evolutionary events are made using molecular data from currently living species. With the availability of genomic data from multiple related species, molecular evolution has become one of the most active and fastest growing fields of study in genomics and bioinformatics. Most studies in molecular evolution rely heavily on statistical procedures based on stochastic process modelling and advanced computational methods including high-dimensional numerical optimization and Markov Chain Monte Carlo. This book provides an overview of the statistical theory and methods used in studies of molecular evolution. It includes an introductory sect...
A grammar of modern Indo-European
A Grammar of Modern Indo-European is a complete reference guide to a living Indo-European language. It contains a comprehensive description of Proto-Indo-European grammar, and offers an analysis of the complexities of the prehistoric language and its reconstruction from its descendant languages. Written in a fresh and accessible style, and illustrated with maps, figures and tables, this book focusses on the real patterns of use of Late Indo-European. The book is well organised and is filled with full, clear explanations of areas of confusion and difficulty. It also contains an extensive English - Indo-European, Indo-European - English vocabulary, as well as detailed etymological notes, designed to provide readers with an easy access to the information they require.An essential reference source for the student of Indo-European as a learned and living language, this work will appeal to students of languages, classics, and the ancient world, as well as to general readers interested in the history of language, and in speaking the direct ancestor of the world's largest language family.
The Selma of the North
Between 1958 and 1970, a distinctive movement for racial justice emerged from unique circumstances in Milwaukee. A series of local leaders inspired growing numbers of people to participate in campaigns against employment and housing discrimination, segregated public schools, the membership of public officials in discriminatory organizations, welfare cuts, and police brutality. The Milwaukee movement culminated in the dramaticÑand sometimes violentÑ1967 open housing campaign. A white Catholic priest, James Groppi, led the NAACP Youth Council and Commandos in a militant struggle that lasted for 200 consecutive nights and provoked the ire of thousands of white residents. After working-class m...
Dialogues on Perception
An elucidation of ideas and insights generated by the paradigm of "early vision," presented in the form of dialogues.
Streptococcal Infections
Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis offers an in-depth examination of the spectrum of hemolytic streptococcal infections and their complications. Additionally, the volume incorporates and discusses aspects of pneumococcal, entrococcal, and oral streptococcal disease. The recent resurgence of rheumatic fever, concomitant outbreaks of severe systemic group A streptococcal infections (often accompanied by toxic shock), an increasing incidence of multiple antibiotic resistance among streptococcal species, and an intensified effort to develop effective streptococcal vaccines have brought renewed attention to the continuing role of streptococci for ...
