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Toxins and Hemostasis
Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but...
International Review of Neurobiology
International Review of Neurobiology
A Herzen Reader
A Herzen Reader presents in English for the first time one hundred essays and editorials by the radical Russian thinker Alexander Herzen (1812–1870). Herzen wrote most of these pieces for The Bell, a revolutionary newspaper he launched with the poet Nikolai Ogaryov in London in 1857. Smugglers secretly carried copies of The Bell into Russia, where it influenced debates over the emancipation of the serfs and other reforms. With his characteristic irony, Herzen addressed such issues as freedom of speech, a nonviolent path to socialism, and corruption and paranoia at the highest levels of government. He discussed what he saw as the inability of even a liberator like Czar Alexander II to commit to change. A Herzen Reader stands on its own for its fascinating glimpse into Russian intellectual life of the 1850s and 1860s. It also provides invaluable context for understanding Herzen’s contemporaries, including Fyodor Dostoevsky and Ivan Turgenev.
The Vascular Endothelium II
This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Biochemical Pharmacology as an Approach to Gastrointestinal Disorders
The Gastrointestinal Section of the International Union of Pharmacology (IUPHAR) was established in 1994 in Montreal, Canada. The establishment of the GI Section recognizes the international progress of gastrointestinal pharmacology, including basic and human studies. The Gastrointestinal Section of IUPHAR organized the first symposium, Biochemical Pharmacology as an Approach to Gastrointestinal Diseases: from Basic Science to Clinical Perspectives, on 10-12 October, 1995, in Pécs, Hungary. The main topics were: Gastrointestinal secretory and excretory fuctions Gastrointestinal motility Biochemical-pharmacological mechanisms in neural and hormonal actions involved in GI functions Main normal and pathological biochemical mechanisms in GI functions GI mucosal injury and protection Molecular mechanisms of premalignant and malignant diseases in GI tract Use of isolated cells and cell cultures in bioochemical-pharmacological studies to approach GI diseases. The presented papers are published in this book.
Progress in Medicinal Chemistry
This book contains six chapters, each of which is a self-contained, thorough review by an expert in the field of a particular topic in medicinal chemistry, bacteriology or pharmacology. Each topic is a currently active subject of research in either the quest for new drugs or a better understanding of the role of known biochemical phenomena. In addition, all of the chapters contain an extensive list of relevant reference books, papers and other publications. The book will be of great interest to medicinal and pharmaceutical chemists, and will serve as a valuable source of reference.
Endothelin and Its Inhibitors
Recent publications have addressed specific aspects of the endothelins, such as their roles in disease or the importance of endothelin receptors. However, in this book the entire field of endothelins is covered. This includes the pathways of endothelin production and their regulation, the local and systemic actions of endothelins, receptors for the endothelins and the signalling pathways employed, and the involvement of endothelins in a range of diseases. Attention is also paid to the development through chemistry, pharmacology and toxicology of endothelin antagonists and endothelin-converting enzyme inhibitors, with mention of all the important members of these drug classes. This leads to well-rounded discussions of the potential therapeutic benefit of endothelin inhibitors.
Endothelin Receptors
Since the discovery of endothelin, major advances have been made in understanding the molecular structure and function of the endothelin receptors. At least two subtypes of receptors, designated ETA and ETB, have been identified through biochemical and pharmacological techniques. These subtypes are cloned and expressed and additional subtypes appear to exist. The biochemical events involved in the signal transduction processes that ultimately activate the cellular machinery involved in the end-organ responses are presented, as are the mechanisms by which the receptors recognize specific and different G-proteins. Functions mediated by the receptors at the cellular, tissue and, organ level are reviewed in detail, as well as the roles that they may play a part in the physiologic and pathophysiologic processes in animals and in humans. This book is unique in its breadth of scope. The most recent and important advances, from the intracellular level of the nucleus to the functional effect that endothelin receptors mediate in intact organs, are compiled and reviewed.
