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Technical Report: Surgical Preparation of Human Brain Tissue for Clinical and Basic Research
Abstract: Background The study of the distinct structure and function of the human central nervous system, both in healthy and diseased states, is becoming increasingly significant in the field of neuroscience. Typically, cortical and subcortical tissue is discarded during surgeries for tumors and epilepsy. Yet, there is a strong encouragement to utilize this tissue for clinical and basic research in humans. Here, we describe the technical aspects of the microdissection and immediate handling of viable human cortical access tissue for basic and clinical research, highlighting the measures needed to be taken in the operating room to ensure standardized procedures and optimal experimental resu...
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma Multiforme
Abstract: The goal of this study was to identify correlations between metabolites from proton MR spectroscopy and genetic pathway activity in glioblastoma multiforme (GBM). Twenty patients with primary GBM were analysed by short echo-time chemical shift imaging and genome-wide expression analyses. Weighed Gene Co-Expression Analysis was used for an integrative analysis of imaging and genetic data. N-acetylaspartate, normalised to the contralateral healthy side (nNAA), was significantly correlated to oligodendrocytic and neural development. For normalised creatine (nCr), a group with low nCr was linked to the mesenchymal subtype, while high nCr could be assigned to the proneural subtype. Moreover, clustering of normalised glutamine and glutamate (nGlx) revealed two groups, one with high nGlx being attributed to the neural subtype, and one with low nGlx associated with the classical subtype. Hence, the metabolites nNAA, nCr, and nGlx correlate with a specific gene expression pattern reflecting the previously described subtypes of GBM. Moreover high nNAA was associated with better clinical prognosis, whereas patients with lower nNAA revealed a shorter progression-free survival (PFS)
Studying Language Change in the 21st Century
The volume brings together contributions by scholars working in different theoretical frameworks interested in systematic explanation of language change and the interrelation between current linguistic theories and modern analytical tools and methodology. Τhe integrative basis of all work is the special focus on phenomena at the interface of semantics and syntax and the implications of corpus-based, quantitative analyses for researching diachrony.
A Pacifist's Life and Death
The shadow of a man standing on the back of a three-wheel pickup truck and smashing with a club the head of another man without the police even pretending to chase the killers was to haunt Greeks for many years. With hindsight, it seemed uncannily like a foretaste of what awaited Greece when the Junta stepped in on April 1967, and put a brutal end to all its democratic illusions. Using written and oral evidence, this book weaves a narrative of the life and death of Grigorios Lambrakis: athletic champion, doctor, politician and Greece’s most committed defender of democracy and peace of the post-Civil War period. It surveys the destiny of a people at key historical junctures, probes their ab...
