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Stereotactic Cisternal Lavage in Patients with Aneurysmal Subarachnoid Hemorrhage with Urokinase and Nimodipine for the Prevention of Secondary Brain Injury (SPLASH): Study Protocol for a Randomized Controlled Trial
Abstract: Background Delayed cerebral infarction (DCI) is a major cause of death and poor neurological outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). Direct intrathecal therapies with fibrinolytic and spasmolytic drugs have appeared promising in clinical trials. However, access to the subarachnoid space for intrathecal drug administration is an unsolved problem so far, especially in patients with endovascular aneurysm securing. We investigate a therapy protocol based on stereotactic catheter ventriculocisternostomy (STX-VCS), a new approach to overcome this problem. The primary objective of this study is to assess whether cisternal lavage with urokinase, nimodipine, and ...
The PRESSURE Score to Predict Decompressive Craniectomy After Aneurysmal Subarachnoid Haemorrhage
Abstract: The prognosis of patients with aneurysmal subarachnoid haemorrhage requiring decompressive craniectomy is usually poor. Proper selection and early performing of decompressive craniectomy might improve the patients' outcome. We aimed at developing a risk score for prediction of decompressive craniectomy after aneurysmal subarachnoid haemorrhage. All consecutive aneurysmal subarachnoid haemorrhage cases treated at the University Hospital of Essen between January 2003 and June 2016 (test cohort) and the University Medical Center Freiburg between January 2005 and December 2012 (validation cohort) were eligible for this study. Various parameters collected within 72 h after aneurysmal su...
Technical Report: Surgical Preparation of Human Brain Tissue for Clinical and Basic Research
Abstract: Background The study of the distinct structure and function of the human central nervous system, both in healthy and diseased states, is becoming increasingly significant in the field of neuroscience. Typically, cortical and subcortical tissue is discarded during surgeries for tumors and epilepsy. Yet, there is a strong encouragement to utilize this tissue for clinical and basic research in humans. Here, we describe the technical aspects of the microdissection and immediate handling of viable human cortical access tissue for basic and clinical research, highlighting the measures needed to be taken in the operating room to ensure standardized procedures and optimal experimental resu...
Delayed Injury Mechanisms After Ischemic and Hemorrhagic Stroke
Topic Editor, Dr. Devin McBride, received financial support from Celense. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing
Abstract: Purpose To evaluate the diagnostic accuracy of epilepsy-dedicated 3 Tesla MRI including post-processing by correlating MRI, histopathology, and postsurgical seizure outcomes. Methods 3 Tesla-MRI including a magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence for post-processing using the morphometric analysis program MAP was acquired in 116 consecutive patients with drug-resistant focal epilepsy undergoing resection surgery. The MRI, histopathology reports and postsurgical seizure outcomes were recorded from the patient's charts. Results The MRI and histopathology were concordant in 101 and discordant in 15 patients, 3 no hippocampal sclerosis/gliosis only...
Oligodendrocyte Lineage and Myelination are Compromised in the Gray Matter of Focal Cortical Dysplasia Type IIa
Abstract: Objectives Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of medically intractable epilepsy. FCDs are characterized by local architectural disturbances of the neocortex and often by a blurred gray-white matter boundary indicating abnormal white matter myelination. We have recently shown that myelination is also compromised in the gray matter of dysplastic areas, since transcripts encoding factors for oligodendrocyte differentiation and myelination are downregulated and myelin fibers appear fractured and disorganized. Methods Here, we characterized the gray matter-associated myelination pathology in detail by in situ hybridization...
Unfuck Your Body
Is your body an asshole? Does it keep you up at night, crave nonstop French fries and ice cream, and try to convince you that exercise is evil? Does it develop weird illnesses and pains for no apparent reason and run out of energy just when you need it the most? Does having a body at all fill you with uncomfortable emotions? Enter Dr. Faith G. Harper, therapist, nutritionist, and bestselling author of Unfuck Your Brain. She explains the emerging science of the gut-brain connection and the vagus nerve so that everyone can understand what's going on in your body and how to make friends with it again, especially if you've experienced trauma or chronic stress. Filled with straight talk and practical exercises so you can reconnect with your physical needs and reactions, work through body shame, manage illness and disability, and implement small changes that make a huge difference in how you feel every day. You are a whole person and it's time to reconnect with yourself!
