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Mouse Models of Innate Immunity
  • Language: en

Mouse Models of Innate Immunity

  • Type: Book
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  • Published: 2016-08-27
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  • Publisher: Humana

The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mous...

Secondary Respiratory Infections in the Context of Acute and Chronic Pulmonary Diseases
  • Language: en
  • Pages: 161
Neuroimmune Interface in Health and Diseases
  • Language: en
  • Pages: 176

Neuroimmune Interface in Health and Diseases

It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively wit...

Pattern Recognition Receptors and Cancer
  • Language: en
  • Pages: 203

Pattern Recognition Receptors and Cancer

The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molec...

Insights in Brain Disease Mechanisms: 2021
  • Language: en
  • Pages: 256

Insights in Brain Disease Mechanisms: 2021

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Modulation of the immune system by bacteria: from evasion to therapy
  • Language: en
  • Pages: 227
Research Advances in Dengue Virus
  • Language: en
  • Pages: 127

Research Advances in Dengue Virus

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Mouse Models of Allergic Disease
  • Language: en

Mouse Models of Allergic Disease

  • Type: Book
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  • Published: 2016-08-23
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  • Publisher: Humana

Over the last half century, a dramatic increase in allergic diseases has been observed throughout industrialized nations, which has resulted in significant worldwide socio-economic challenges. In Mouse Models of Allergic Disease: Methods and Protocols, a wide range of expert contributors provide detailed protocols for the design and execution of experiments to thoroughly analyze critical elements associated with a diverse range of allergic diseases, all through the lens of mouse models that accurately recapitulate clinically relevant aspects of the respective human disease. The volume opens with a section featuring techniques essential for effective ex vivo cell isolation and evaluation of s...

Science
  • Language: en
  • Pages: 1012

Science

  • Type: Book
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  • Published: 2011
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  • Publisher: Unknown

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