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The Practice of Medicinal Chemistry
The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process. The only book available dealing with the practical aspects of medicinal chemistry Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry
Federal Register
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L' Odyssée D'Isabelle de la Morinière
Grand-mère Isabelle, adossée au platane presque centenaire, nous fit de douces confidences sur sa vie peu ordinaire. "Mes enfants, cet arbre je l'ai planté le jour de ma Première communion. Je l'ai toujours entendu chanter, comme une douce musique, celle de mon enfance en ce beau pays de Normandie."Dans la nuit du 14 avril 1912, nous la retrouvons en voyage de noces avec son mari, le diplomate allemand Burkhard Ortmann, sur le Victorian pris dans les glaces au large de Terre-Neuve. Non loin de là, le Titanic coulait corps et biens au cours de son voyage inaugural.Même après 50 ans, en ce beau jour ensoleillé d'été 1962, la plainte de la sirène lançant pour la première fois dans le cosmos glacial son S.O.S. de détresse, à jamais gravé dans sa mémoire, retentissait encore. La Princesse Isabelle de la Morinière ne savait pas quel destin l'attendait, un destin aux contours flous, mais plein de bonheur, d'espérance et de compassion.
French XX Bibliography
Provides the most complete listing available of books, articles, and book reviews concerned with French literature since 1885. The bibliography is divided into three major divisions: general studies, author subjects (arranged alphabetically), and cinema. This book is for the study of French literature and culture.
Intensive Exposure Experiences in Second Language Learning
This volume brings together studies from learning contexts that provide intensive exposure to the target language: naturalistic immersion (immigration and study abroad), intensive instruction, and informal intensive environments in foreign language settings. Its chapters yield much needed evidence on the role of context of acquisition and highlight the unique role of intensive exposure in second language learning.
Basal Implantology
This manual will help oral implantologists to understand the principles that underlie the use of basal implants as a means to provide simple solutions to complex and highly demanding clinical situations without the need for prior bone grafting. It will also serve as a richly illustrated practical guide to application of the technique. The book is in three parts, the first of which discusses basic principles and related themes, including osteogenesis, osseointegration, cortical anchorage stability, biomechanics, surgical techniques, and basal implant prosthodontics. Step-by-step guidance is then offered on the application of these principles, focusing on operating techniques, 3D treatment planning, transitional and final screw-secured prostheses, and postoperative follow-up. The third part of the book addresses a wide range of clinical situations that can be treated by basal implantology, with particular attention to the treatment of high, thin alveolar ridges and the atrophic maxilla and mandible and to the correction of previous implant failures, as well as complications and postimplantation neuropathies.
To be Free and French
An ambitious new vision of French citizenship from the perspective of Africans and Antilleans living in the colonies and mainland France. Lorelle Semley explores the ways in which these colonial subjects used French democratic ideals to demand rights and redefine the meanings of freedom and 'Frenchness'.
Mental Retardation
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Gonadotropic Hormones
Hormonal Proteins and Peptides, Volume XI: Gonadotropic Hormones deals with gonad stimulating hormones that cause precocious sexual maturity. This book begins by reviewing the relationship of the chemical structure to the biological activity of gonadotropins and chorionic hormones, followed by a brief presentation on the in vitro bioassay methods. A comprehensive discussion on some aspects of the molecular mechanism of gonadotropin action is also provided. This publication concludes with an analysis of the immunobiology of gonadotropins. This book is intended for endocirnologists, but is also useful for medical practitioners and researchers concerned with gonadotropic hormones.
