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Progress in High Temperature Physics and Chemistry
Progress in High Temperature Physics and Chemistry
BACE
BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics fo...
Resilience
This book explores the concept of ‘resilience’ in the context of militaries and militarization. Focusing on the U.S., Britain, Canada, Australia, and continental Europe, it argues that, post-9/11, there has been a shift away from ‘trauma’ and towards ‘resilience’ in framing and understanding human responses to calamitous events. The contributors to this volume show how resilience-speech has been militarized, and deeply entrenched in imagined communities. As the concept travels, it is applied in diverse and often contradictory ways to a vast array of experiences, contexts, and scientific fields and disciplines. By embracing diverse methodologies and perspectives, this book reflects on how resilience has been weaponized and employed in highly gendered ways, and how it is central to neoliberal governance in the twenty-first century. While critical of the use of resilience, the chapters also reflect on more positive ways for humans to respond to unforeseen challenges.
DNA-Encoded Libraries
This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening (HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as to graduate students and scholars who are interested in this rapidly improving technology.
Memory and History
How does the historian approach memory and how do historians use different sources to analyze how history and memory interact and impact on each other? Memory and History explores the different aspects of the study of this field. Taking examples from Europe, Australia, the USA and Japan and treating periods beyond living memory as well as the recent past, the volume highlights the contours of the current vogue for memory among historians while demonstrating the diversity and imagination of the field. Each chapter looks at a set of key historical and historiographical questions through research-based case studies: How does engaging with memory as either source or subject help to illuminate th...
FCC Record
None
Management of Heart Failure
Medical Management of Heart Failure brings together the current knowledge on the medical management of heart failure into one cohesive volume. It includes copious illustrations and photographic material that will explain the techniques and medical management of patients with heart failure in an effective modern format.
Bedlam at Botany Bay
Madness stalked the colony of New South Wales and tracing its wild path changes the way we look at our colonial history. What happened when people went mad in the fledgling colony of New South Wales? In this important new history, we find out through the tireless correspondence of governors and colonial secretaries, the delicate descriptions of judges and doctors, the brazen words of firebrand politicians, and the heartbreaking letters of siblings, parents and friends. We also hear from the mad themselves. Legal and social distinctions faded as delusion and disorder took root — in convicts exiled from their homes and living under the weight of imperial justice, in ex-convicts and small settlers as they grappled with the country they had taken from its Indigenous inhabitants, and in government officers and wealthy colonists who sought to guide the course of European history in Australia. These stories of madness are woven together into a narrative about freedom and possibilities, unravelling and collapse. Bedlam at Botany Bay looks at people who found themselves not only at the edge of the world, but at the edge of sanity. It shows their worlds colliding.
Habsburg Sons
Habsburg Sons describes Jewish participation in the Habsburg Army, 1788-1918, concentrating on World War I. Approximately 300,000-350,000 Jews fought in the Austro-Hungarian Armies on all fronts; of these, 30,000–40,000 died of wounds or illness, and at least 17% were taken prisoner in camps all over Russia and Central Asia. Many soldiers were Orthodox Ostjuden, and over 130 Feldrabbiner (chaplains) served among them. Antisemitism was present but generally not overt. The book uses personal diaries and newspaper articles (most available in English for the first time) to describe their stories, and compares the experiences of Jews in German, Russian, and Italian armies.
