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Interstitial Pulmonary Diseases
This book discusses basic and clinical aspects of selected topics in interstitial lung disease and the pathogenic mechanisms of pulmonary fibrosis. Topics include the pathogenesis of interstitial fibrosis from the initial injury to the excessive accumulation of collagens in lung parenchyma; detailed analysis of the role of fibroblasts, mast cells and growth factors in the induction of fibrogenesis; collagens, collagenases, and proteoglycans; and hypersensitivity, pneumonitis and asbestosis. Other topics include morphological aspects, including molecular biology techniques, imaging methods, functional respiratory tests, and pulmonary arterial hypertension; and sleep disorders in patients with ILD. This book provides important information for physicians, surgeons, pulmonary researchers, molecular pathologists, biomedical researchers and students, and others interested in interstitial lung disease.
The Drama of DNA
Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside. This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.
Bioregenerative Engineering
A unique, comprehensive reference that integrates the molecular, cellular, physiological, pathological, and engineering aspects of regenerative processes Bioregenerative engineering is an emerging discipline based on applying engineering principles and technologies to regenerative medicine. It induces, modulates, enhances, and/or controls regenerative processes by using engineering approaches to improve the restoration of the structure and function of disordered or lost molecules, cells, tissues, and organs. This reference systematically summarizes bioregenerative engineering principles, technologies, and current research to help scientists understand biological regeneration and design new t...
The Nose
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Cell Movement and Neoplasia
Cell Movement and Neoplasia presents the proceedings of the annual meeting of the Cell Tissue and Organ Culture Study Group, held at the Janssen Research Foundation, Beerse, Belgium, in May 1979. The book covers papers about the structural functional correlates in cell movement and invasion and an approach to the in vitro study of neoplastic cell social behavior with a light microscopy method of bidirectional image transfer. The text then presents papers about cell interactions and invasion in vitro and cell movement and invasion in vivo. Geneticists, oncologists, pathologists, cytologists, and other scientists from diverse disciplines will find the book invaluable.
Microparticulate Systems for the Delivery of Proteins and Vaccines
This practical guide offers concise coverage of the scientific and pharmaceutical aspects of protein delivery from controlled release microparticulate systems-emphasizing protein stability during encapsulation and release.
Human Identification: The Use of DNA Markers
The ongoing debate on the use of DNA profiles to identify perpetrators in criminal investigations or fathers in paternity disputes has too often been conducted with no regard to sound statistical, genetic or legal reasoning. The contributors to Human Identification: The Use of DNA Markers all have considerable experience in forensic science, statistical genetics or jurimetrics, and many of them have had to explain the scientific issues involved in using DNA profiles to judges and juries. Although the authors hold differing views on some of the issues, they have all produced accounts which pay due attention to the, sometimes troubling, issues of independence of components of the profiles and of population substructures. The book presents the considerable evolution of ideas that has occurred since the 1992 Report of the National Research Council of the U.S. Audience: Indispensable to forensic scientists, laying out the concepts to all those with an interest in the use of genetic information. The chapters and exhaustive bibliography are vital information for all lawyers who must prosecute or defend DNA cases, and to judges trying such cases.
Chemical Biology of Glycoproteins
Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.
