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Nuclear Magnetic Resonance
As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: ""NMR of Proteins and Nucleic Acids"" and ""NMR of Carbohydrates, Lipids and Membranes"". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.
Adenoviral Vectors for Gene Therapy
Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope ...
Characterization, regulation, and interactions within the protease web
This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.
Update 1991
A comprehensive survey of recent advances is given in this Update. The wide spectrum of experimental and clinical investigations include the pathophysiologic, diagnostic and therapeutic aspects.
How Gut and Brain Control Metabolism
Obesity is an epidemic problem not limited to Western society, but also in emerging industrial nations with large populations, especially in Asia. The connection between the gut and the brain is probably one of the most promising therapeutic targets for the treatment of obesity and metabolic syndrome. This book brings together reviews on the current understanding of how the gut and brain communicate in the regulation of metabolism. Individual chapters explore novel aspects of this interaction. A comprehensive update on the roles of smell and taste, the gut microbiome, and novel gut-derived neuropeptides in regulating metabolism via the brain is offered. Furthermore, the regulation of insulin sensitivity in the brain is discussed in detail. Providing an overview of the most recent findings, 'How Gut and Brain Control Metabolism' could spark in the reader new ideas or approaches, thus leading to much-needed new medical treatments. Physicians with an involvement in the treatment of metabolic disease and scientists performing research in the fields of nutrition and obesity will find this book a valuable addition to their bookshelves.
Clinical Neuroendocrinology
Clinical Neuroendocrinology, a volume in the Handbook of Clinical Neurology Series gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts. - All contributors are recognized experts in the different fields of clinical neuroendocrinology - The book provides expanded coverage on hypothalamic mechanisms in human pathophysiology - The book includes current perspectives, diagnosis and treatment of pituitary diseases
Handbook of Magnetic Resonance Spectroscopy In Vivo
This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscl...
Nutrient Timing
Sports nutrition has evolved beyond what to eat and how much to eat to now include the question of when to eat. A hot topic in sports nutrition, nutrient timing is a dietary concept that takes into account time as a missing dimension in athletic performance and recovery. Not only is the consumption of nutrients in ideal amounts and proportions important, but the timing with which they are administered is also of prime importance—the right nutrients at the ideal time to affect performance and muscular growth. Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery presents the most authoritative text to date that scientifically examines the contemporary topic of nutrie...
Obesity and Lipotoxicity
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
