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Degradome-focused RNA Interference Screens to Identify Proteases Important for Breast Cancer Cell Growth
Abstract: Proteases are known to promote or impair breast cancer progression and metastasis. However, while a small number of the 588 human and 672 murine protease genes have been extensively studied, others were neglected. For an unbiased functional analysis of all genome-encoded proteases, i.e., the degradome, in breast cancer cell growth, we applied an inducible RNA interference library for protease-focused genetic screens. Importantly, these functional screens were performed in two phenotypically different murine breast cancer cell lines, including one stem cell-like cell line that showed phenotypic plasticity under changed nutrient and oxygen availability. Our unbiased genetic screens i...
Heat-shock Protein 90 Controls the Expression of Cell-cycle Genes by Stabilizing Metazoan-specific Host-cell Factor HCFC1
Abstract: Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding. Their function in the cytosol has been well studied. Notably, chaperones are also present in the nucleus, a compartment where proteins enter after completing de novo folding in the cytosol, and this raises an important question about chaperone function in the nucleus. We performed a systematic analysis of the nuclear pool of heat-shock protein 90. Three orthogonal and independent analyses led us to the core functional interactome of HSP90. Computational and biochemical analyses identify host cell factor C1 (HCFC1) as a transcriptional regulator that depends on HSP90 for its stability. HSP90 was required to maintain the expression of HCFC1-targeted cell-cycle genes. The regulatory nexus between HSP90 and the HCFC1 module identified in this study sheds light on the relevance of chaperones in the transcription of cell-cycle genes. Our study also suggests a therapeutic avenue of combining chaperone and transcription inhibitors for cancer treatment
Steampunk Akte Asien
Im Archiv der Organisation Nachtfalter liegen die Geheimnisse der Welt katalogisiert und geordnet. Seit Jahrtausenden sammeln ihre Agenten die Geschichten über phantastische Wesen, Erfindungen an den Grenzen menschlicher Imagination und natürlich die Knochen der Erde. Lassen Sie sich in 13 Akten der Organisation nach Asien entführen. Sie reichen zurück bis in die tiefste Vergangenheit Indonesiens und erzählen uns von dort bis in die Gegenwart die Geschichten eines Kontinents voller Vielfalt: Von den Geheimnissen, die die Große Mauer unüberwindlich machten, von dem verborgenen Weg nach Shangri-La, von den mechanischen Rüstungen der Samurai und den Automaten chinesischer Ingenieure. Doch die Akten berichten auch von der Bedrohung, die diese Wunder für sich vereinnahmen will: Die Kolonialherren Europas.
Gazeta Lwowska
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Parliamentary Papers
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Sessional Papers
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Cloaks and Furs
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