Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Heat-shock Protein 90 Controls the Expression of Cell-cycle Genes by Stabilizing Metazoan-specific Host-cell Factor HCFC1
Abstract: Molecular chaperones such as heat-shock proteins (HSPs) help in protein folding. Their function in the cytosol has been well studied. Notably, chaperones are also present in the nucleus, a compartment where proteins enter after completing de novo folding in the cytosol, and this raises an important question about chaperone function in the nucleus. We performed a systematic analysis of the nuclear pool of heat-shock protein 90. Three orthogonal and independent analyses led us to the core functional interactome of HSP90. Computational and biochemical analyses identify host cell factor C1 (HCFC1) as a transcriptional regulator that depends on HSP90 for its stability. HSP90 was required to maintain the expression of HCFC1-targeted cell-cycle genes. The regulatory nexus between HSP90 and the HCFC1 module identified in this study sheds light on the relevance of chaperones in the transcription of cell-cycle genes. Our study also suggests a therapeutic avenue of combining chaperone and transcription inhibitors for cancer treatment
Stress-induced Nuclear Condensation of NELF Drives Transcriptional Downregulation
Abstract: In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear condensates upon stress in human cells. Condensate formation requires NELF dephosphorylation and SUMOylation induced by stress. The intrinsically disordered region (IDR) in NELFA is necessary for nuclear NELF condensation and can be functionally replaced by the IDR of FUS or EWSR1 protein. We find that biomolecular condensation facilitates enhanced recruitment of NELF to promoters upon stress to drive transcriptional downregulation. Importantly, NELF condensation is required for cellular viability under stressful conditions. We propose that stress-induced NELF condensates reported here are nuclear counterparts of cytosolic stress granules. These two stress-inducible condensates may drive the coordinated downregulation of transcription and translation, likely forming a critical node of the stress survival strategy
Bazaar and State in Iran
The Tehran Bazaar has always been central to the Iranian economy and indeed, to the Iranian urban experience. Arang Keshavarzian's fascinating book compares the economics and politics of the marketplace under the Pahlavis, who sought to undermine it in the drive for modernisation and under the subsequent revolutionary regime, which came to power with a mandate to preserve the bazaar as an 'Islamic' institution. The outcomes of their respective policies were completely at odds with their intentions. Despite the Shah's hostile approach, the bazaar flourished under his rule and maintained its organisational autonomy to such an extent that it played an integral role in the Islamic revolution. Conversely, the Islamic Republic implemented policies that unwittingly transformed the ways in which the bazaar operated, thus undermining its capacity for political mobilisation. Arang Keshavarizian's book affords unusual insights into the politics, economics and society of Iran across four decades.
Medical Epigenetics
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many o...
Hsp90 in Cancer: Beyond the Usual Suspects
Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
Voices of a Massacre
In July 1988, the Islamic Republic of Iran agreed to bring an end to the brutal eight-year war with Iraq. Over the next two months, under the orders of Supreme Leader Ayatollah Khomeini, political prisoners around the country were secretly brought before a tribunal panel that would later become known as the Death Commission. They were not told what was happening and did not know that one ‘wrong’ answer concerning their faith or political affiliation would send them straight to the gallows. Thousands of men and women were condemned to death, many buried in mass graves in Khavaran Cemetery in the vicinity of Tehran. Through eyewitness accounts of survivors, research by scholars and memories of children and spouses of the deceased, Voices of a Massacre reconstructs the events of that bloody summer. Over thirty years later, the Iranian government has still not officially acknowledged that they ever took place.
The Green Movement in Iran
The Green Movement in Iran contains Hamid Dabashi’s most important writings on the Iran’s June 2009 election, its tumultuous aftermath, and the characteristics and aspirations of the emerging Green Movement. These analyses range from close analysis of the nature of the events to the Green Movement’s historical background and future political consequences. The writings have been modified and updated for book publication. The volume presents Dabashi’s account of the events since June 12, 2009—the Election Day itself—and his recap of highlights of the build-up period to the mass protests. He provides insightful background for events on the ground, dealing with debates about the cred...
Tortured Confessions
3 The Islamic Republic
The Gulf Directory
None
The Palaeolithic Settlement of Asia
This book provides the first analysis and synthesis of the evidence of the earliest inhabitants of Asia before the appearance of modern humans 100,000 years ago. Asia has received far less attention than Africa and Europe in the search for human origins, but is no longer considered of marginal importance. Indeed, a global understanding of human origins cannot be properly understood without a detailed consideration of the largest continent. In this study, Robin Dennell examines a variety of sources, including the archaeological evidence, the fossil hominin record, and the environmental and climatic background from Southwest, Central, South, and Southeast Asia, as well as China. He presents an authoritative and comprehensive framework for investigations of Asia's oldest societies, challenges many long-standing assumptions about its earliest inhabitants, and places Asia centrally in the discussions of human evolution in the past two million years.
