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Mathematical Modelling of Chromosome Replication and Replicative Stress
DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?. A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.
Ships And Maritime Landscapes
This volume gathers 88 contributions related to the theme ‘Ships and Maritime Landscapes’ of the Thirteenth International Symposium on Boat and Ship Archaeology (ISBSA 13) held in Amsterdam on the 7th to 12th October 2012. The articles include both papers and poster presentations by experts in the field of nautical archaeology, history of ships and shipbuilding, and naval architecture. The contributions deal not only with the theme of maritime landscapes but also with a variety of ship related subjects, like regional watercraft, construction and typology, material applications and design, outfitting, reconstruction and current research.
Franciscan Organisation in the Mendicant Context
Emanating from the tradition of the Italian hermit communities the Franciscans developed organisational structures already early in their history, allowing them to offer pastoral care on a wide scale. This process of transition led firstly to constitutional structures as defined in the order's early legislation but it also occurred within relationship networks at different levels, in the context of Church and papacy, within the different European regions and before the background of the emerging Canon Law. The term "organisation" has been given a wide definition in the articles published in this volume. They offer a survey of general issues related to the structuring and running of religious orders as well as a number of case studies. Comparisons with other mendicant orders offer an analysis of the issues in a wider context.
Livonia, Rus’ and the Baltic Crusades in the Thirteenth Century
This monograph by Anti Selart is the first comprehensive study available in English on the relations between northern crusaders and Rus'. Selart re-examines the central issues of this crucial period of establishing the medieval relations of the Catholic and Orthodox worlds like the Battle on the Ice (1242) and the role of Alexander Nevsky using the relevant source material of both “sides”. He also considers the wide context of the history of crusading and the whole Eastern and Northern Europe from Hungary and Poland to Denmark, Finland, and Sweden in 1180-1330. This monograph contests the existence of the constitutive religious conflict and extensive aggressive strategies in the region – the ideas which had played a central role in modern historiography and ideology.
Geographic and Executive Indexes
Volume 1, Part 1, Sections 1-6) Entries 1-10069; Volume 1, Part 2, Sections 7-18) Entries 10070-22383); Volume 1, Part 3, Name and Keyword Index; Volume 2, Geographic and Executive Indexes.
