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G Protein-coupled Receptors
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. The book lies between the fields of chemical biology, molecular pharmacology, and medicinal chemistry.
G Protein-Coupled Receptors - Modeling and Simulation
G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of ...
Recent Advances in Artificial Intelligence Research and Development
Artificial intelligence in all its forms is increasingly interwoven into all our lives, and remains one of the most lively areas of discussion and interest in technology today. This book presents the proceedings of the 20th International Conference of the Catalan Association for Artificial Intelligence (CCIA’2017): ‘Recent Advances in Artificial Intelligence Research and Development’, held in Deltebre, Terres de l'Ebre, Spain, in October 2017. Despite its title, this annual conference is not only for researchers from the Catalan Countries, but is an international event which attracts participants from countries all around the world. In total, 41 original contributions were submitted to...
Allosterism in Drug Discovery
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future. This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.
An Introduction to Conservation Biology
"An Introduction to Conservation Biology is well suited for a wide range of undergraduate courses, as both a primary text for conservation biology courses and a supplement for ecological and environmental science courses. This new edition focuses on engaging students through videos and activities, and includes new pedagogy to scaffold students' learning. Coverage of recent conservation biology events in the news-such as global climate change and sustainable development-keeps the content fresh and current"--
Hunger and Hope
Readable, thought-provoking, and beneficial for those who want to comprehend the plight of the rural poor, Hunger and Hope examines the world of those living near, on, and over the edge of poverty in developing countries. Their aspirations, struggles, and daily challenges are revealed with compassion and genuine understanding of the risks they face to sustain themselves and their families. The text is rich with lucid and methodical observations of the economic processes that shape agricultural development in impoverished countries. The author builds in an imaginative way on his extensive experience assisting farmers and assessing the impacts of agricultural interventions. Real-world illustrations of the policies and practices that not only create opportunities and food security but also create hardships show that, while progress has been made in reducing poverty and hunger, there is a need to do more.
Killer Birds
The barn owl may look cute, but it’s a killer! In order to survive, this predator silently glides through the night to pounce on unsuspecting prey. In this book, readers meet many other predatory birds, including the peregrine falcon, bald eagle, and red kite. Stunning photographs of these birds in action accompany accessible text and facts about each bird’s habitat, food, and weapons. The main text supports science curricula by highlighting predator-prey relationships as well as points about conservation and body part adaptation to certain kinds of hunting.
The Killings in Colombia
4. The drug trade
How Eagles Grow Up
Eagles are majestic, awe-inspiring birds. Bald eagles were so inspiring that they became the symbol of the United States of America. In this fun, easy-to-read book, readers learn how bald and golden eagles grow from eggs in the nest into the great birds of prey that soar through the skies. Vibrant photographs illustrate the various stages of the eaglet's life, as well as the nests they call home. Fun facts are featured throughout this engaging and entertaining book.
G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors ...
