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ATP and the Heart
ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.
Current and Future Applications of Magnetic Resonance in Cardiovascular Disease
This timely monograph focuses exclusively on the current and emerging use of magnetic resonance imaging (MRI) and spectroscopy (MRS) as clinical diagnostic and scientific investigative tools in cardiovascular disease. While MRI is now primarily being used to depict morphology, the innate benefit of this modality is unparalleled precision in the quantification of cardiac function and blood flow. This potential is intriguingly explored in a number of chapters that describe the utilization of MR techniques for myocardial tagging, myocardial perfusion, and coronary flow quantification. The continuous development of MRS as a realistic probe for in vivo elucidation of myocardial metabolism, myocar...
Cardiovascular Magnetic Resonance
Magnetic resonance imaging of the heart allows a quick and exact evaluation of global and regional pump function, regional myocardial wall motion, myocardial perfusion and coronary blood flow. Some of these parameters must also be analyzed under stress conditions to identify myocardial ischemia. By combining these functional parameters with high-resolution anatomical images, which are even sufficient to depict the coronary arteries, magnetic resonance imaging has become one of the most important noninvasive procedures to study the condition of the heart and is being increasingly used in the clinical setting. Therefore, it is important not only to optimize and evaluate the technique in specialized centers, but also for a broad variety of users to become familiar with the wide range of applications for this method. In this book, which is aimed at cardiologists, radiologists, and technical assistants, the physical fundamentals and scanning techniques are clearly described. In addition, practical guidelines for the anatomical planning of the examination and for patient care are offered. The accompanying CD-ROM contains additional figures and numerous videos.
Translational Cardiology
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques cu...
Heart Metabolism in Failure
Heart failure continues to be a major public health problem in the United States with close to half a million new cases diagnosed each year. Moreover, deaths from heart failure are on the increase, in part because of advances in the treatment of other fatal diseases, and in part from the prevalence of lifestyles indifferent to the risk factors for heart disease. This is not to say that no progress has been made in the treatment of heart failure. While for many years treatment was confined to the management of the symptoms, in recent years with the advent of ACE inhibitor and ß blacker therapies, real improvements in cardiac function and life expectancy have been achieved (Volume 4B, Leier)....
Normal Human Tissue and Cell Culture, Part A
Normal Human Tissue and Cell Culture, Part A
Heart Failure: A Companion to Braunwald's Heart Disease E-book
Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, ...
Cardiovascular Magnetic Resonance Spectroscopy
The application of magnetic resonance spectroscopy (MRS) to the cardiovascular system is a relatively new phenomenon. Its ability to noninvasively examine myocardial metabolism has led to its use to answer basic questions in animal models of normal and diseased myocardium. Extension of these investigations into the realm of human myocardial metabolism has been made possible by the advent of relatively high-field magnets with spectroscopy capabilities and sufficient bore dimensions to allow human studies. While ongoing and future studies promise to enhance our understanding of myocardial metabolism, their success will, in part, depend on a thorough understanding of the technical and biologic ...
Heart Hypertrophy and Failure
Heart Hypertrophy and Failure brings together leading basic scientists and clinicians, presenting improved knowledge of the pathophysiology and treatment of the condition. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system in health and disease. The papers presented describe fundamental mechanisms underlying changes in the cellular machinery during the development of cardiac hypertrophy and heart failure. Audience: Students, scientists, clinical and experimental cardiologists who seek to understand and manage the perplexing problems of hypertrophy and heart failure.
Diastolic Relaxation of the Heart
viewed as rolling downhili from an uphill or This book represents an edited compilation of the scientific presentations given at an Interna high-energy state. This transition results from tional Symposium on the Physiology of Diastole the opening of membrane pores that allow in Health and Disease, September 11 to 14, calcium to rush into the cytosol, triggering 1986, in Cambridge, Massachusetts. Numerous excitation-contraction coupling. If the energy studies have documented the importance of available to sarcoplasmic reticular and sarcolem diastolic dysfunction in clinical heart disease. In mal calcium pumps was insufficient to remove recent years clinicians have become increasingly this cal...
