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Heart Metabolism in Failure
Heart failure continues to be a major public health problem in the United States with close to half a million new cases diagnosed each year. Moreover, deaths from heart failure are on the increase, in part because of advances in the treatment of other fatal diseases, and in part from the prevalence of lifestyles indifferent to the risk factors for heart disease. This is not to say that no progress has been made in the treatment of heart failure. While for many years treatment was confined to the management of the symptoms, in recent years with the advent of ACE inhibitor and ß blacker therapies, real improvements in cardiac function and life expectancy have been achieved (Volume 4B, Leier)....
Cell Culture Techniques in Heart and Vessel Research
In the cardiovascular sciences, an increasing demand for the use of modern methods of cell biology has developed. The use of specific cell culture models of the various tissues involved is essential for most of these novel approaches. This book meets the demand for acomprehensive and easy accessible source for cell cul- ture methods in cardiovascular research as it was not previously available. The basic methods for cultures of cardiomyocytes (embryonic and adult), endothelial cells (micro- and macrovascular), smooth muscle cells and pericytes are described in detail by an international selection of experts. Special chapters discuss the use of growth factors and attachment substrates, techniques for co-cultures, cultures on permeable filter membranes and microcarrier cultures. The methodological descriptions are sufficiently detailed for an immediate application in the laboratory. All chapters also contain a critical evaluation of alternative approaches.
Cytochrome Systems
This volume is based on the proceedings of an International Symposium on "Cytochrome Systems: Molecular Biology and Bioenergetics" that was held at Selva di Fasano near Bari, Italy, between April 7 and 11,1987. It contains papers covering the subjects discussed at the Symposium, contributed both by participants of the meeting and by some invited speakers who were not able to attend. The aim of the Symposium was to bring together experts in various rese arch strategies currently being applied to the study of cytochrome systems, including molecular genetics, protein chemistry, enzymology of electron transfer and protonmotive activity in energy-transducing biological mem branes. Because of the ...
Applications
Applications
Myocardial Ischemia: Mechanisms, Reperfusion, Protection
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events i...
Bioelectrochemistry III
This book contains aseries of review papers related to the lectures given at the Third Course on Bioelectrochemistry held at Erice in November 1988, in the framework of the International School of Biophysics. The topics covered by this course, "Charge Separation Across Biomembranes, " deal with the electrochemical aspects of some basic phenomena in biological systems, such as transport of ions, ATP synthesis, formation and maintenance of ionic and protonic gradients. In the first part of the course some preliminary lectures introduce the students to the most basic phenomena and technical aspects of membrane bioelectrochemistry. The remaining part of the course is devoted to the description o...
Metal Ions in Biological Systems
Thirty chapters provide a handbook-like treatment of magnesium and its function in the environment, its bioinorganic chemistry, its role for plants and in animal and human nutrition, its biochemistry and physiology, and its relation to human health and disease. The last 20 years have seen a prolifer
Metal-Carbon Bonds in Enzymes and Cofactors
The occurrence of a wide variety of metal-carbon bonds in living organisms, ranging from bacteria to humans, is only recently recognized. Of course, the historical examples are the B12 coenzymes containing cobalt-carbon bonds, but now such bonds are also known for nickel, iron, copper, and other transition metal ions. There is no other comparable book; MILS-6, written by 17 experts, summarizes the most recent insights into this fascinating topic.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
