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Pulmonary Arterial Hypertension
Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of the pressure in the lung vasculature through exercise, leading to progressive worsening of hemodynamics, right ventricular hypertrophy, right heart insufficiency and finally right heart failure. This book focuses on pulmonary arterial hypertension, a rare and progressive subgroup of pulmonary hypertension, which is today incurable and terminally faal. Classification of pulmonary arterial hypertension, its pathology, and strategies for future therapy will be of interest both to those suffering from the disease and those who take care of patients. This volume will also engage physicians and other scientists contributing to an understanding of the pathophysiology of pulmonary arterial hypertension and attempting to extend life of humans with pulmonary arterial hypertension by developing causal and curative therapies.
Carbonic Anhydrase
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
Food and Addiction
The food environment has changed dramatically and is now dominated by foods with unnaturally high levels of sugar, fat, and salt that are intensely rewarding. Scientific evidence has increased rapidly in the last few decades that these types of foods are capable of triggering addictive processes, which may be a key driver in the rising rates of obesity and diet-related disease around the globe. Food and Addiction: A Comprehensive Handbook, Second Edition provides a multidisciplinary review of the most cutting-edge science on the contribution of addictive processes to how we consume food. Top experts in the field of nutrition, addiction, psychology, psychiatry, neuroscience, epidemiology, public health, marketing, and policy come together to provide a scoping view of this rapidly evolving scientific area that has important implications for the well-being and health of adults and children around the globe.
Affective Ecocriticism
Scholars of ecocriticism have long tried to articulate emotional relationships to environments. Only recently, however, have they begun to draw on the complex interdisciplinary body of research known as affect theory. Affective Ecocriticism takes as its premise that ecocritical scholarship has much to gain from the rich work on affect and emotion happening within social and cultural theory, geography, psychology, philosophy, queer theory, feminist theory, narratology, and neuroscience, among others. This vibrant and important volume imagines a more affective—and consequently more effective—ecocriticism, as well as a more environmentally attuned affect studies. These interdisciplinary ess...
Appetite Control
Ongoing research aims to identify additional targets and agents in order to develop drugs that meet the safety standards required for the chronic therapy of morbid obesity. This text is a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism.
Computer-Assisted Lead Finding and Optimization
Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in chemometrics, molecular modeling and three-dimensional QSAR approaches. Relatively new mathematical methods such as genetic algorithms or artificial neural networks and fuzzy logic have found their application in rational molecular design. As is amply illustrated, based on recent developments in these disciplines, important progress has been made in lead finding strategies. This is of great importance to the pharmaceutical industry. Thus, all scientists investigating quantitative structure-activity relationships in their broadest sense, in medicinal, agricultural, or environmental chemistry will benefit from this book.
New Oxford Textbook of Psychiatry
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has b...
Filling Up
Benefiting readers ranging from students researching topics in food, psychology, and eating disorders to parents and general readers seeking to better understand a variety of issues regarding the psychology of food and eating, this book examines a wide range of complex issues, such as emotional eating, food as a form of social bonding and personal identity, and changes in eating throughout the lifespan. Filling Up: The Psychology of Eating addresses a broad subject area that some may rarely think about but that actually encompasses topics relevant to all individuals, regardless of culture or ethnicity. Eating is often an emotionally charged event, and as such, it involves powerful feelings, ...
