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Pulmonary Arterial Hypertension
Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of the pressure in the lung vasculature through exercise, leading to progressive worsening of hemodynamics, right ventricular hypertrophy, right heart insufficiency and finally right heart failure. This book focuses on pulmonary arterial hypertension, a rare and progressive subgroup of pulmonary hypertension, which is today incurable and terminally faal. Classification of pulmonary arterial hypertension, its pathology, and strategies for future therapy will be of interest both to those suffering from the disease and those who take care of patients. This volume will also engage physicians and other scientists contributing to an understanding of the pathophysiology of pulmonary arterial hypertension and attempting to extend life of humans with pulmonary arterial hypertension by developing causal and curative therapies.
Calcium, Vitamin D and Health
Calcium is the main mineral in the body, involved in a variety of structural and functional roles. The maintenance of calcium homeostasis is perhaps the most studied function of vitamin D. This Special Issue of Nutrients, “Calcium, Vitamin D and Health” contains 12 original publications and two reviews investigating the contribution of (mainly) vitamin D and calcium on relevant health outcomes in a variety of populations, which reflect the evolving and broad interest of researchers on this topic.
Food and Addiction
The food environment has changed dramatically and is now dominated by foods with unnaturally high levels of sugar, fat, and salt that are intensely rewarding. Scientific evidence has increased rapidly in the last few decades that these types of foods are capable of triggering addictive processes, which may be a key driver in the rising rates of obesity and diet-related disease around the globe. Food and Addiction: A Comprehensive Handbook, Second Edition provides a multidisciplinary review of the most cutting-edge science on the contribution of addictive processes to how we consume food. Top experts in the field of nutrition, addiction, psychology, psychiatry, neuroscience, epidemiology, public health, marketing, and policy come together to provide a scoping view of this rapidly evolving scientific area that has important implications for the well-being and health of adults and children around the globe.
Appetite Control
The volume ‘Appetite Control’ provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify addit...
Carbonic Anhydrase
Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of in
New Oxford Textbook of Psychiatry
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has b...
Affective Ecocriticism
Scholars of ecocriticism have long tried to articulate emotional relationships to environments. Only recently, however, have they begun to draw on the complex interdisciplinary body of research known as affect theory. Affective Ecocriticism takes as its premise that ecocritical scholarship has much to gain from the rich work on affect and emotion happening within social and cultural theory, geography, psychology, philosophy, queer theory, feminist theory, narratology, and neuroscience, among others. This vibrant and important volume imagines a more affective--and consequently more effective--ecocriticism, as well as a more environmentally attuned affect studies. These interdisciplinary essay...
Computer-Assisted Lead Finding and Optimization
Computer-assisted techniques are well-integrated in modern drug discovery and used for the finding of new leads, the optimization of receptor or enzyme affinity, as well as of pharmacokinetic and physicochemical properties. In this book an account is found of current strategies used in computer-assisted drug design. Important topics include progress in chemometrics, molecular modeling and three-dimensional QSAR approaches. Relatively new mathematical methods such as genetic algorithms or artificial neural networks and fuzzy logic have found their application in rational molecular design. As is amply illustrated, based on recent developments in these disciplines, important progress has been made in lead finding strategies. This is of great importance to the pharmaceutical industry. Thus, all scientists investigating quantitative structure-activity relationships in their broadest sense, in medicinal, agricultural, or environmental chemistry will benefit from this book.
