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Severe Plasma Prekallikrein Deficiency: Clinical Characteristics, Novel KLKB1 Mutations, and Estimated Prevalence
Abstract: Background Severe plasma prekallikrein (PK) deficiency is an autosomal-recessive defect characterized by isolated activated partial thromboplastin time prolongation. To date, no comprehensive methodologically firm analysis has investigated the diagnostic, clinical, and genetic characteristics of PK deficiency, and its prevalence remains unknown. Patients/Methods We described new families with PK deficiency, retrieved clinical and laboratory information of cases systematically searched in the (gray) literature, and collected blood of these cases for complementary analyses. The Genome Aggregation Database (gnomAD) and the population-based Gutenberg Health Study served to study the pr...
Platelets in Thrombotic and Non-Thrombotic Disorders
This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Hämostaseologie
Das neue Standardwerk für Weiterbildung und klinische Praxis: Von den molekularen Grundlagen bis zur praktisch-klinischen Fragestellung, von den klassischen Gebieten bis zu aktuellen Aspekten der Endothelzellbiologie umfaßt das Lehr- und Nachschlagewerk das gesamte Wissensspektrum der Hämostaseologie. Fundiert, didaktisch klar und praxisbezogen, bietet es Ihnen Informations-Sicherheit mit jedem Griff.
Swiss Medical Weekly
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Cancer-Associated Thrombosis
Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
This House of Noble Deeds
Celebrates the medical achievements and pays homage to the history of New York's mount Sinai Hospital system On January 15, 1852, nine men representing various Hebrew charitable organizations came together to establish the Jews' Hospital in New York with a vision of offering free medical care to the indigent Hebrews in the City who were unable to provide for themselves during their illness. This was the beginning of The Mount Sinai Hospital. Now, a century and a half later, This House of Noble Deeds celebrates the scientific and medical achievements of The Mount Sinai Hospital. From its original 45-bed building, the Mount Sinai Medical Center has developed into a state-of-the-art facility co...
Infections in Hematology
Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens ...
