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Stalwarts of the local music scene, Mel & Joe have played, sung and done it all. Household names since they first appeared on television in 1971, Mel & Joe are not only two of Singapore’s best-loved musical talents, they are living proof of our rich musical past and vibrant present. From the early days of Talentimeand the black-and-white broadcasts of RTS (Radio Television Singapore) to their glorious heydays with one of Singapore's top bands, Gypsy, they continue to rock on with passion. Throughout their musical journey, family support – parents, siblings, wives and daughters – has been instrumental in giving them the love and inspiration that was needed to strive to continue to be the best they can be musically. Music brings the brothers even closer, and at the same time, continues to forge a strong spirit of camaraderie that they share with their audiences.
Reprint of the original, first published in 1872. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
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Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals...