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Cerebrospinal Fluid in Neurology and Psychiatry
Scientists have speculated as to the nature of cerebrospinal fluid (CSF) - "the third circulation" or "vital spirit" for centuries. Just what is this mysterious bathing solution of the central nervous system? Is it a vehicle of transport for an "animal spirit" directing all our activities, as thought by Galen (Singer, 1956) or but a "modified tap water" (Halliburton, 1917)? With the advent of lumbar puncture, cerebrospinal fluid has become a readily available and important means of studying disease affecting the nervous system. In recent years, many sophisticated tools including com puter guided gas chromatography/mass spectrometry and high performance liquid chromatography have made it possible to identify and quantify many constituents of this fluid. The CSF has an enormous, though largely "untapped", potential in aiding diagnosis and evaluating treatment of many neurological, psychiatric and systemic disorders. As the ependyma is only a diffusional barrier between the CSF and extracellular fluid of the brain for many compounds, changes in the concentration of these compounds in the CSF may reflect disease processes in the brain.
Silent Myocardial Ischemia
Although some investigators have questioned the importance and even the existence of silent myocardial ischemia, documentation presented at this two day symposium leaves little doubt about its existence and importance. It has been estimated that about 3 million of the estimated 4 million angina sufferers in the United states have frequent episodes of silent myocardial ischemia. Although it is not possible to define how many Americans die due to silent ischemia, it has been suggested that the mortality rate may exceed hundreds of thousands of victims annually. Unfortunately, there still remains a lack of definitive information as to why some ischemic events are painless. Some suggest the conc...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders
Recent Advances in Clinical Therapeutics, Volume 1: Hypertension, Cardiovascular Disease, Analgesics, and Endocrine Disorders presents the clinical development in therapeutics. This book covers three major areas, including endocrinology, analgesics, and hypertension and other cardiovascular risk factors. Organized into four parts encompassing 20 chapters, this volume begins with an overview of the stepped care approach to the treatment of hypertension. This text then summarizes the advances in various fields of medicine, including concepts or principles of pharmacotherapy. Other chapters consider the value of treating mild hypertension and the combined use of sodium nitroprusside and a chronotropic drug in congestive heart failure. This book discusses as well the methods in the therapy of diabetes mellitus. The final chapter deals with the three general approaches by which therapeutic agents are developed, namely, clinical methods, pharmacological methods, and chemical methods. This book is a valuable resource for clinical pharmacologists, primary care physicians, and allied health professionals.
