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Pain is an unpleasant sensation. It is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". Pain is part of the body's defence system: it triggers mental problem-solving strategies that seek to end the painful experience, and it promotes learning, making repetition of the painful situation less likely. The nociceptive system transmits signals that usually trigger the sensation of pain, it is a critical component of the body's ability to react to damaging stimuli and it is part of a rapid-warning relay instructing the central nervous system to initiate reactions for minimising injury. This book presents the latest research in the field from around the globe.
The previous editions of The Rat Nervous System were indispensable guides for those working on the rat and mouse as experimental models. The fourth edition enhances this tradition, providing the latest information in the very active field of research on the brain, spinal cord, and peripheral nervous system. The structure, connections, and function are explained in exquisite detail, making this an essential book for any graduate student or scientist working on the rat or mouse nervous system. - Completely revised and updated content throughout, with entirely new chapters added - Beautifully illustrated so that even difficult concepts are rendered comprehensible - Provides a fundamental analysis of the anatomy of all areas of the central and peripheral nervous systems, as well as an introduction to their functions - Appeals to researchers working on other species, including humans
Portrait of a Community examines emerging kinship structures as embedded in the social and cultural history of a river valley in a central coastal Fujian province from the ninth through thirteenth centuries. The book demonstrates how cultural innovation often begins at a local level.
In 17th and 18th century China, Buddhists and Confucians alike flooded local Buddhist monasteries with donations. As gentry numbers grew faster than the imperial bureaucracy, traditional Confucian careers were closed to many; but visible philanthropy could publicize elite status outside the state realm. Actively sought by fund-raising abbots, such patronage affected institutional Buddhism. After exploring the relation of Buddhism to Ming Neo-Confucianism, the growth of tourism to Buddhist sites, and the mechanisms and motives for charitable donations, Timothy Brook studies three widely separated and economically dissimilar counties. He draws on rich data in monastic gazetteers to examine the patterns and social consequences of patronage.
This book covers biomass modification to facilitate the industrial degradation processing and other characteristics of feedstocks and new technologies for the conversion of lignocelluloses into biofuels and other products.
This book gives a comprehensive view of the most recent major international research in the field of tolerancing, and is an excellent resource for anyone interested in Computer Aided Tolerating. It is organized into 4 parts. Part 1 focuses on the more general problems of tolerance analysis and synthesis, for tolerancing in mechanical design and manufacturing processes. Part 2 specifically highlights the simulation of assembly with defects, and the influence of tolerances on the quality of the assembly. Part 3 deals with measurement aspects, and quality control throughout the life cycle. Different measurement technologies and methods for estimating uncertainty are considered. In Part 4, different aspects of tolerancing and their interactions are explored, from the definition of functional requirement to measurement processes in a PLM approach.
Disordered proteins are relatively recent newcomers in protein science. They were first described in detail by Wright and Dyson, in their J. Mol. Biol. paper in 1999. First, it was generally thought for more than a decade that disordered proteins or disordered parts of proteins have different amino acid compositions than folded proteins, and various prediction methods were developed based on this principle. These methods were suitable for distinguishing between the disordered (unstructured) and structured proteins known at that time. In addition, they could predict the site where a folded protein binds to the disordered part of a protein, shaping the latter into a well-defined 3D structure. ...
In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. Included within the scope are T cell immunity; Antigen presentation; Alloreactivity; Pancreas and islet cell transplantation; Allogeneic bone marrow transplantation Models of tolerance induction; Xenotransplantation and The swine leukocyte antigen (SLA) complex. This book gathers the latest research in the exciting new field of transplantation immunology.
Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. * Now Available Online as part of the Life Sciences package via ScienceDirect * Highly respected review series with an impact factor in 2003 of 7.424 and ranked number 8/114